Results 61 to 70 of about 5,620 (149)
Advanced Science, EarlyView.In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
P20.15.A DESCRIPTIVE ANALYSIS OF A SERIES OF H3 K27-ALTERED DIFFUSE MIDLINE GLIOMAS IN CHILDREN AND ADULT POPULATION [PDF]
Neuro Oncol, 2023 Abstract BACKGROUND Molecular biomarkers have gained importance in providing diagnostic information for brain and spinal cord tumors. Diffuse midline gliomas (DMG) are now defined as H3 K27-altered. H3 K27M mutations were first described in pediatric diffuse pontine gliomas but can also be encountered
C Salva de Torres +3 more
europepmc +2 more sources
Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]
, 2013 Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
core +2 more sources
Brain Pathology, Volume 36, Issue 2, March 2026.ADAPTR recommendations for Adult‐type Diffuse Gliomas in Resource‐restrained settings. Abstract The fifth edition of the WHO classification of CNS Tumors (WHO CNS5) has revised the diagnostic and grading criteria for Adult‐type Diffuse Gliomas (ADGs) by integrating molecular parameters with histologic features.
Vani Santosh +11 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Epigenomic dysregulation contributes to Alzheimer's disease (AD) and related tauopathies. Acetyl‐CoA synthetase 2 (ACSS2), a nuclear‐localized metabolic enzyme in neurons, supports histone acetylation and learning‐related gene expression.
Gabor Egervari +10 more
wiley +1 more source
Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer [PDF]
, 2015 Despite recent advances in cancer management, colorectal cancer (CRC) remains the third most common cancer and a major health-care problem worldwide. MicroRNAs have recently emerged as key regulators of cancer development and progression by targeting ...
Abdulla, MH +7 more
core +2 more sources
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source
Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. [PDF]
, 2012 DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation.
Bultmann, Sebastian +9 more
core +3 more sources
CellsPediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their aggressive pathophysiology and limited treatment options.
Leo F. Nonnenbroich +5 more
doaj +1 more source
Long noncoding RNAs in prostate cancer: overview and clinical implications. [PDF]
, 2016 Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to ...
Feng, Felix Y, Malik, Bhavna
core +3 more sources