Results 71 to 80 of about 5,620 (149)

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

DDEL-05. PHARMACOKINETIC ASSESSMENT OF CONVECTION-ENHANCED DELIVERY OF SMALL MOLECULE DRUGS FOR H3 K27-ALTERED DIFFUSE MIDLINE GLIOMA [PDF]

Neuro Oncol, 2023
Abstract H3 K27-altered diffuse midline gliomas (DMG) are uniformly lethal tumors for which no therapy has been found to be effective. The blood-brain barrier (BBB) restricts uptake and accumulation of systemically administered drugs in the brain.
Julian Rechberger, Jacob Anderson, Jizhi Ge, Liang Zhang, David Daniels   +4 more
europepmc   +2 more sources

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

Study on diagnosis and differential diagnosis of common tumors in the posterior fossa of children based on diffusion-weighted imaging

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the imaging diagnosis and differential diagnosis methods for common tumors in the posterior fossa of children, and to propose a flow chart for the diagnosis of common tumors in the posterior fossa of children based on the limited
DING Xing-hua, ZHU Ying-feng, ZHANG Chao, ZHU Yi-qian, ZHANG Rong   +4 more
doaj   +1 more source

ADA2 Forms Nuclear Condensates with GCN5 and ATP‐Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study unveils a novel GAA (GCN5‐ADA2‐ACL) complex that forms nuclear condensates to boost local acetyl‐CoA, facilitating histone acetylation and gene transcription in rice meristems. The research underscores the role of ADA2's disordered region in complex condensation and ACL's role in acetyl‐CoA production.
Yaping Yue, Tingting Lu, Xiaoyuan Guo, Biao Liu, Shiteng Lv, Heba A. M. Abdalla, Xuelei Lai, Ruihui Zhang, Jianpin Guo, Yu Zhao, Dao‐Xiu Zhou, Shaoli Zhou   +11 more
wiley   +1 more source

Clinical Characteristics and Prognostic Factors in H3 K27- altered Diffuse Midline Gliomas: A 64 Cases Retrospective Cohort Analysis

, 2023
Abstract Purpose This study aims to systematically assess patient characteristics, identify clinical factors guiding treatment decisions, and predict the prognosis of H3 K27-altered Diffuse Midline Glioma (DMG/K27M). Methods A retrospective review of 64 consecutive DMG/K27M patients was conducted.
Liqian Zhao, Zibin Song, Luxiong Fang, Yu Zeng, Lei Han, Zhengming Zhan, Peng Chai, Ke Ji, Ruizhe Chen, Ziting He, Guanglong Huang, Jun Pan, Ye Song   +12 more
openaire   +1 more source

Bridging the genetical environmental gap in Parkinson's disease through epigenetics [PDF]

, 2016
Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting 2% of the population over 60 years old, yet the exact molecular mechanism underlying its pathogenesis remains elusive.
Blundell, Renald, De Weerdt, L., Sanchez, D., Shueb, A.   +3 more
core   +1 more source

Phosphorylation event changes the RNA binding mode of EZH2 disordered segment

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Polycomb repressive complex 2 (PRC2), which exhibits an important gene silencing role in development and differentiation, has been shown to interact with several long non‐coding RNAs (lncRNAs) that influence its function and determine its localization.
Beáta Szabó, András Micsonai, József Kardos, Ágnes Tantos   +3 more
wiley   +1 more source

Molecular alterations in pediatric brainstem gliomas [PDF]

, 2017
BackgroundDiffuse intrinsic pontine gliomas (DIPGs) have a dismal prognosis. Previously, diagnosis was based on a typical clinical presentation and magnetic resonance imaging findings.
Anna Raunio, Atte Karppinen, Jarno Satopää, Juha Hernesniemi, Leena Valanne, Mikaela Porkholm, Minna Oinas, Olli Tynninen, Reetta Vainionpää, Sanna-Maria Kivivuori, Tarja Salonen, Virve Pentikäinen   +11 more
core   +1 more source