Integration of omics data in the diagnosis and therapy of glioblastoma
Brain Pathology, Volume 36, Issue 1, January 2026.Integration of omics data in the diagnosis and therapy of glioblastoma. Abstract Since the 2016 update of the WHO Classification of Tumors of the Central Nervous System, omics data have been officially integrated into the diagnostic process for glioblastoma, the most prevalent and aggressive primary malignant brain tumor in adults.
Constantin Möller +3 more
wiley +1 more source
Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity [PDF]
, 2015 Excitatory amino acids play a key role in both adaptive and deleterious effects of stressors on the brain, and dysregulated glutamate homeostasis has been associated with psychiatric and neurological disorders. Here, we elucidate mechanisms of epigenetic
Bigio, B +6 more
core +1 more source
RE: Comments on cIMPACT‐NOW Update 11
Brain Pathology, EarlyView.
Henning Leske +2 more
wiley +1 more source
Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]
, 2018 Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A +2 more
core
Trapping DNA Replication Origins from the Human Genome [PDF]
, 2013 Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins’ structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking
Aladjem +14 more
core +2 more sources
Advanced Science, Volume 12, Issue 44, November 27, 2025.Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li +24 more
wiley +1 more source
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression [PDF]
, 2015 The primers used for the amplification of the indicated genes.(DOCX 17Â ...
Fuchao Guo +7 more
core +3 more sources
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy
Medicinal Research Reviews, Volume 45, Issue 6, Page 1651-1661, November 2025.ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra +9 more
wiley +1 more source
Diffuse Midline H3 K27-Altered Gliomas in the Spinal Cord: A Systematic Review
Proceedings of IMPRSBackground: Gliomas account for 80-90% of all intramedullary spinal cord tumors (IMSCTs). Though rare compared to brain tumors, spinal cord gliomas can cause significant morbidity and mortality. Diffuse midline gliomas (DMGs) with H3 K27M-mutation, first introduced in the 2016 WHO classification, are high-grade tumors with aggressive behavior and poor ...
Mohammad Faizan Khan +6 more
openaire +1 more source
Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output [PDF]
, 2014 Growth factor receptor levels are aberrantly high in diverse cancers, driving the proliferation and survival of tumor cells. Understanding the molecular basis for this aberrant elevation has profound clinical implications.
Brognard, J. +12 more
core +1 more source