Results 1 to 10 of about 94,416 (98)
The histamine H3 receptor: from gene cloning to H3 receptor drugs [PDF]
Nature Reviews Drug Discovery, 2005 Since the cloning of the histamine H(3) receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well ...
Leurs, R. +3 more
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The FASEB Journal, 2007 The histamine H 3 receptor (H 3 R) exists as multiple splice isoforms. Using GTPγS binding and MAPK phosphorylation assays, we compared constitutive signaling by human H 3 (445) and H 3
Timothy A. Esbenshade +9 more
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Histamine H3 Receptor Antagonists Go to Clinics
Biological and Pharmaceutical Bulletin, 2008 Within the recent years novel lead optimisations for histamine H(3) receptor antagonists made their way from bench to bedside. Structure-activity relationships, cross-affinities and side effects as well as pharmacokinetic profiling will be discussed on selected promising compound series.
Kerstin, Sander +2 more
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Identification of histamine H3 receptor antagonists
The FASEB Journal, 2007 Histamine H 3 receptors (H 3 R) regulate the release of histamine and other neurotransmitters in the brain. H 3 R have been shown to modulate many functions, including feeding, sleep, and cognition, making them ...
Andria Lee Del Tredici +14 more
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The Histamine H3 Receptor: Structure, Pharmacology, and Function [PDF]
Molecular Pharmacology, 2016 Among the four G protein-coupled receptors (H1-H4) identified as mediators of the biologic effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive expression in the nervous system and the large variety of isoforms generated by alternative splicing of the corresponding mRNA.
Gustavo, Nieto-Alamilla +4 more
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Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists
Behavioural Pharmacology, 2014 To determine the potential of histamine H3 receptor (H3R) ligands as new antiepileptic drugs (AEDs), aromatic ether, and diether derivatives (1-12) belonging to the nonimidazole class of ligands, with high in-vitro binding affinity at human H3R, were tested for their in-vivo anticonvulsive activity in the maximal electroshock (MES)-induced and ...
Sadek, Bassem +7 more
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The gastric H3 receptor: a review.
The Yale journal of biology and medicine, 1994 Previous in vivo and in vitro studies from our laboratory have revealed a line of pharmacological evidence supporting histamine H3 receptor(s) involvement in the control of gastric acid secretion. We have recently extended our studies to the human gastric tumoral cell HGT-1.
M J, Lewin +3 more
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The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors. [PDF]
J Biol Chem, 2023 Xu J, Pittenger C.
europepmc +1 more source
The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia. [PDF]
J Psychopharmacol, 2023 Arumuham A +5 more
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Discovery of a Tritiated Radioligand with High Affinity and Selectivity for the Histamine H3 Receptor. [PDF]
ACS Med Chem Lett, 2023 Mönnich D +5 more
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