Results 131 to 140 of about 94,535 (216)

Establishment of a mouse model of propylthiouracil‐induced antineutrophil cytoplasmic antibody‐associated vasculitis

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract summarizes our study in which we established a novel murine model of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis. Neutrophil recruitment was induced using thioglycolate, followed by timed administration of propylthiouracil and phorbol 12‐myristate 13‐acetate to generate DNase I‐resistant neutrophil ...
Sakiko Masuda, Momo Uchizawa, Chihiro Terasaka, Takumi Abe, Tetsuro Nakamura, Yuka Nishibata, Yusho Ueda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu   +9 more
wiley   +1 more source

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

Animal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li, Fansen Lin, Hongzhi Gao, Yun Zhao, Yuqi Liu   +4 more
wiley   +1 more source

Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands. [PDF]

PLoS One, 2019
Schaller D, Hagenow S, Stark H, Wolber G.   +3 more
europepmc   +1 more source

A Review on Magnesium Based Metal Hydrides for Thermal Energy Storage Systems

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The hydrogen storage in metal hydrides is an imminent, innovative, and environmentally beneficial approach that offers benefits for example, an ample amount of storage and elasticity in terms of thermodynamics necessary for hydrogen absorption and release.
Asif Nizam, Prem Kumar Chaurasiya, Vinod Kumar Sharma, Ranjith Krishna Pai   +3 more
wiley   +1 more source

AR71, Histamine H₃ Receptor Ligand-In Vitro and In Vivo Evaluation (Anti-Inflammatory Activity, Metabolic Stability, Toxicity, and Analgesic Action). [PDF]

Int J Mol Sci
Stasiak A, Honkisz-Orzechowska E, Gajda Z, Wagner W, Popiołek-Barczyk K, Kuder KJ, Latacz G, Juszczak M, Woźniak K, Karcz T, Szczepańska K, Jóźwiak-Bębenista M, Kieć-Kononowicz K, Łażewska D.   +13 more
europepmc   +1 more source

Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy. [PDF]

Sleep, 2020
Setnik B, McDonnell M, Mills C, Scart-Grès C, Robert P, Dayno JM, Schwartz JC.   +6 more
europepmc   +1 more source

Sustainable Graphene Oxide–Intercalated Bentonite Composite for the Effective Removal of Imidacloprid From Water: Adsorption Performance, Isotherm, and Kinetics

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Water is a fundamental necessity for our existence, but its rapid contamination is causing devastating effects on the environment and health of living species worldwide. Adsorptive removal of pollutants is one of the popular water treatment techniques because of its simplicity, affordability, and the broad range of available adsorbents.
Priyanka Negi, Brij Bhushan, Arunima Nayak, Pallavi Singh   +3 more
wiley   +1 more source

Histamine H₃ receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice. [PDF]

Mol Brain
Kaita S, Morishita Y, Kobayashi K, Nomura H.   +3 more
europepmc   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Covalent Inhibition of the Histamine H₃ Receptor. [PDF]

Molecules, 2019
Wágner G, Mocking TAM, Kooistra AJ, Slynko I, Ábrányi-Balogh P, Keserű GM, Wijtmans M, Vischer HF, de Esch IJP, Leurs R.   +9 more
europepmc   +1 more source