Results 61 to 70 of about 94,535 (216)

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

Advanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang, Xin Hua, Ziwei Fan, Jiaxin Zhao, Yuan Zhang, Qiaoyi Zhang, Xi Qu, Shengli Pan, Bingbing Wan, Shiyin Yang, Jia Li, Xu Zhang   +11 more
wiley   +1 more source

Multitargeting Histamine H₃ Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives. [PDF]

Molecules, 2023
Łażewska D, Kaleta M, Zaręba P, Godyń J, Dubiel M, Honkisz-Orzechowska E, Doroz-Płonka A, Więckowska A, Stark H, Kieć-Kononowicz K.   +9 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Fishing for histamine H3 receptor functions [PDF]

Acta Physiologica, 2017
openaire   +2 more sources

Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep-Wake Cycle Disorder. [PDF]

Front Pharmacol, 2022
Alhusaini M, Eissa N, Saad AK, Beiram R, Sadek B.   +4 more
europepmc   +1 more source

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae

Advanced Science, EarlyView.
MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia, Yunna Zheng, Nan Yang, Jing Chen, Xi Wu, Ximing Zheng, Danrui Cui, Ruijin Wang, Xunli Lu, Dongli Wang, You‐liang Peng, Qian Chen   +11 more
wiley   +1 more source

Structure-activity studies with histamine H3-receptor ligands.

Journal de pharmacie de Belgique, 1995
Analogues of thioperamide have been synthesised and tested in vitro on rat cerebral cortex to explore structure-activity relationships with the intention of designing compounds which do not possess the thiourea group of thioperamide and which may have improved brain penetration.
Ganellin, C. R., Fkyerat, A., Hosseini, S. K., Khalaf, Y. S., Piripitsi, A., Tertiuk, W., Arrang, J. M., Garbarg, M., Ligneau, X., Schwartz, J. C.   +9 more
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Histamine H3 receptor (HRH3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Substituted Purines as High-Affinity Histamine H₃ Receptor Ligands. [PDF]

Pharmaceuticals (Basel), 2022
Espinosa-Bustos C, Leitzbach L, Añazco T, Silva MJ, Campo AD, Castro-Alvarez A, Stark H, Salas CO.   +7 more
europepmc   +1 more source