Results 241 to 250 of about 20,346,263 (306)

Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS. [PDF]

Nat Commun
Whitley MJ, Dyba M, Chakrabarti M, Smith BP, Chan AH, Denson JP, Messing SA, Lin K, Cornilescu G, Balius TE, Nissley DV, McCormick F, Maciag AE, Simanshu DK.   +13 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Regional tau burden tracks with lower microglial HLA class II transcription in the human brain. [PDF]

Front Neurosci
Li F, Jin S, Wang P, Yang H, Zhuang X, Feng F, Cheng P.   +6 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Star formation powers optical line emission from the CGM. [PDF]

Sci Adv
Zhang H, Xie L, Qu Z, Zaritsky D, Ho LC, Bao M, Fontanot F, Hirschmann M, Liu C, De Lucia G, Wang E, Zheng H.   +11 more
europepmc   +1 more source

H II Regions in Finite H I Clouds.

The Astronomical Journal, 1967
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Genetically Distinct African Swine Fever Virus Genotype II Variant in Wild Boar, Spain, 2025-2026. [PDF]

Emerg Infect Dis
Gallardo C, Marcet-Houben M, Agüero M, Nieto R, Casado N, Soler A, Ruano MJ, Villalba R, Fernández-Pinero J, Simón A, Pérez C, Gómez C, García C, Labrador M, Argilaguet J, Coronado L, Majó N, Aguilera-Sepulveda P, Aldea I, Gabaldón T, Gómez MB, Arias M.   +21 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source