Inferring Geographic Spread of Flaviviruses Through Analysis of Hypervariable Genomic Regions. [PDF]
Sánchez-Nava J +2 more
europepmc +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Tailoring the Hydrogen Diffusion in Polycrystalline WO<sub>3</sub> Thin Films by a p-n Heterojunction. [PDF]
Hecker TK +4 more
europepmc +1 more source
Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applications. [PDF]
Hashemi S +5 more
europepmc +1 more source
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Development of a multi-epitope vaccine against Helicobacter pylori using a novel saRNA technology through an immunoinformatics approach. [PDF]
Razzak A, Ahmed F, Mahmud MT.
europepmc +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles With Applications to Drug Shelf-Life Estimation. [PDF]
Wang L, Han Y, Liu W, Bretz F.
europepmc +1 more source
Radiatively and shock excited H2 in Magellanic H II regions.
F. P. Israel, J. Koorneef
openalex +1 more source

