Autophagosome marker, LC3, is released extracellularly via several distinct pathways
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Designing a Multi-Epitope Vaccine Against NOTCH1 and NOTCH4: A Computational Approach for Triple-Negative Breast Cancer. [PDF]
Teimoori P, Khatir K, Heidari M.
europepmc +1 more source
Radiatively and shock excited H2 in Magellanic H II regions.
F. P. Israel, J. Koorneef
openalex +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Fibre orientations in collagen-containing tissues revealed with computational scattered light imaging and polarimetric second harmonic generation microscopy. [PDF]
Ettema L +5 more
europepmc +1 more source
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Utilizing multivariate pattern analysis to uncover the neurobiological underpinnings of communication disorders in children with bilateral spastic cerebral palsy: insights from morphological and structural connectivity changes. [PDF]
Hu J +7 more
europepmc +1 more source
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation. [PDF]
Chen YY +6 more
europepmc +1 more source

