Results 151 to 160 of about 11,383,904 (312)

Factors Associated With Omalizumab Response in Chronic Spontaneous Urticaria: Are There Age‐Related Differences?

Acta Paediatrica, EarlyView.
ABSTRACT Aim This study aimed to explore clinical and laboratory markers of omalizumab response in paediatric and adult chronic spontaneous urticaria (CSU) patients. Methods The study included 32 children and 67 adults with CSU receiving omalizumab, and 29 paediatric and 30 adult healthy controls; associations with treatment response were evaluated ...
Güler Yıldırım Nalbant, Raif Coşkun, Nilay Çalışkan, Merve Karaca Şahin, Aslı Berivan Topçak, Muhammed Fatih Erbay, Çağla Öztürk Turan, Hilal Güngör, Hamit Boloğur, Hasan Tunç Şarman, Şule Papağan, Ömer Yılmaz Ulutaş, Şefika İlknur Kökçü Karadağ, Özlem Terzi, Deniz Özçeker   +14 more
wiley   +1 more source

Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat‐Dose Administration for up to 14 Days

Alimentary Pharmacology &Therapeutics, EarlyView.
In this Phase 1 study, linaprazan glurate (LG) demonstrated rapid onset of intragastric acid suppression, achieving a pH > 4 within 10 to 60 min, and maintained pH control, with a 24‐h pH > 4 holding time ratio above 95% at 50 mg and 75 mg twice‐daily doses. AUC and Cmax of linaprazan, the main metabolite of LG, increased in proportion to LG dose.
Kajsa Larsson, Kjell Andersson, Gunilla Huledal, Jouni Junnila, Kristofer Katkits Nilsson, Elham Yektaei, Matjaž Fležar, Peter Unge   +7 more
wiley   +1 more source

NESTED POLYMERASE CHAIN REACTION FOR DETECTION OF HELICOBACTER PYLORI IN GASTRIC BIOPSY SPECIMENS

, 2020
. Sensitivity and specificity are important for tests used to defect Helicobacter pylori infection from gastric biopsy specimens. Molecular methods, such as PCR and nested PCR, are sensitive methods for H. pylori detection.
Nested Pcr For H, Pylori, Detection
core  

The TOP‐GERD Trial: Comparative Efficacy of Tegoprazan Versus Pantoprazole in the Treatment of Erosive Oesophagitis in a Non‐Asian Population

Alimentary Pharmacology &Therapeutics, EarlyView.
In this randomized, double‐blind trial in Mexican adults with erosive oesophagitis, tegoprazan did not significantly improve the primary 4‐week ITT healing endpoint versus pantoprazole (88.9% vs. 79.4%; p = 0.33), but produced faster symptom improvement. Encouraging per‐protocol and severe‐oesophagitis findings warrant confirmation.
José M. Remes‐Troche, Luis Raúl Valdovinos‐García, C. Prakash Gyawali, José Luis Vargas‐Basurto, Carlos Alberto Reyes‐Medina, Gisselle Vanessa González‐Hernández, A. Rafael Bernal Mendez, H. H. Barragán Cordova, Pablo Thomas‐Dupont, Peter Grube‐Pagola   +9 more
wiley   +1 more source

Anatomy and Histology of the Midgut of Atopozelus opsimus (Heteroptera: Reduviidae)

Acta Zoologica, EarlyView.
ABSTRACT Atopozelus opsimus Elkins, 1954 (Heteroptera: Reduviidae) preys on forest and agricultural pests but also feeds on extrafloral nectar; however, its alimentary canal is poorly understood. The aim was to describe the anatomy and histology of the A. opsimus midgut. The alimentary canal of female and male A.
Bruna Silva Lisboa, José Eduardo Serrão, Jamile Fernanda Silva Cossolin, Germano Leão Demolin Leite, José Cola Zanuncio, Sebastião Lourenço de Assis Júnior, Pedro Guilherme Lemes   +6 more
wiley   +1 more source

Editorial: H. pylori Guidelines: To Implement and How-That Is the Question. [PDF]

Aliment Pharmacol Ther
Hunt RH.
europepmc   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Editorial: H. pylori Guidelines: To Implement and How-That Is the Question. Authors' Reply. [PDF]

Aliment Pharmacol Ther
Quach DT, Malfertheiner P.
europepmc   +1 more source

Prospective screening of dyspeptic patients by Helicobacter pylori serology: a safe policy? The Italian Helicobacter pylori Study Group.

, 1997
BACKGROUND AND STUDY AIMS: Endoscopic screening of all dyspeptic patients is not cost-effective, nor is it feasible in many health-care delivery systems.
STANGHELLINI VINCENZO, CORINALDESI ROBERTO, The Italian Helicobacter pylori Study Group, PALLI DOMENICO, VAIRA DINO, MENEGATTI MARCELLO, MIGLIOLI MARIO, NERI, Matteo   +7 more
core  

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source