Results 81 to 90 of about 262,778 (317)
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
Inspecting Driving Forces of Business Cycles in Korea
East Asian Economic Review, 2019 This paper sets up a new Keynesian model with external habit to explore the role of each shock over business cycles in Korea. The estimated model via maximum likelihood shows that the productivity shock plays a pivotal role in explaining the output ...
Yongseung Jung
doaj +1 more source
The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep
Advanced Science, EarlyView.Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller +3 more
wiley +1 more source
Reconstructive Habits: John Dewey on Human Functioning
Ethics in Progress, 2018 The academic strife to parse, investigate and adjust human functioning establishes varieties of at least three key concepts: behavior, action, activity. Depending on the general approach chosen, human functioning is therefore defined in a certain way and
David Jaitner
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Habiter, habitants et habitats
Calenda, 2021 Le domicile constitue un enjeu sociétal majeur, parce qu’il est le creuset de nombreux aspects de la vie personnelle et sociale, parce qu’il apparaît de plus en plus comme un lieu pluri-finalisé, lieu de projets et objet de nombreux réinvestissements.
openaire +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
A genealogical map of the concept of habit
Frontiers in Human Neuroscience, 2014 The notion of information processing has dominated the study of the mind for over six decades. However, before the advent of cognitivism, one of the most prominent theoretical ideas was that of Habit.
Xabier E Barandiaran +1 more
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Advanced Science, EarlyView.The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang +22 more
wiley +1 more source
Habits and Dispositions in Frank Ramsey’s Philosophy
European Journal of Analytic PhilosophyThis paper examines Ramsey’s use of the concepts of habit and disposition, challenging the common interpretation that he employs them interchangeably in his theory of belief.
Alice Morelli
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Comment rompre avec l’habitude ?
Espace populations sociétés, 2015 Because of car use negative externalities, travel behaviours are likely to change. But the force of habit generates inertia. Accompanying individually the user in a process of change, individualized marketing programs provide to break with the habits of ...
Anaïs Rocci
doaj +1 more source