Results 241 to 250 of about 94,938 (303)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Getting Over It: Maternal Stress and Gut Microbiome Manipulations Do Not Affect Rates of Offspring Habituation During Long Bouts of Stress. [PDF]

J Exp Zool A Ecol Integr Physiol
Black TC, Demas GE, Wellman CL, Cusick JA.   +3 more
europepmc   +1 more source

A multi-scale mathematical framework for modelling the dynamic nature of autism spectrum disorder symptoms: integrating predictive coding, information theory, and network principles. [PDF]

Front Psychiatry
Adamou M, Kehagias A, Antoniou G.
europepmc   +1 more source

Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin. [PDF]

Toxicol Sci
Wray C, Castañeda-Monsalve V, Engelmann B, Rolle-Kampczyk UE, Schweiger N, Gutsfeld S, Ghosh D, Kader S, Tyler CR, Jehmlich N, Tal T.   +10 more
europepmc   +1 more source

Factors Modulating the Effects of Juvenile Social Isolation on Adult Social Behavior in Rodents. [PDF]

Dev Psychobiol
Leventhal MB, Kawatake-Kuno A, Lidoski A, Morishita H.   +3 more
europepmc   +1 more source

Japanese quail (Coturnix japonica) selected for high social motivation rely on conspecifics for buffering but not learning in sociocognitive tasks. [PDF]

PLoS One
Seressia J, Morel A, Cornilleau F, Lemarchand J, Lansade L, Nawroth C, Calandreau L, Ferreira VHB.   +7 more
europepmc   +1 more source

Nighttime sleep promotes mechanosensory habituation in Drosophila

Lowe SA, Wilson AD, Chen K, Jepson JE.
europepmc   +1 more source

Habituation: A history [PDF]

Neurobiology of Learning and Memory, 2009
Richard F Thompson
exaly   +3 more sources

Models of habituation in infancy

Trends in Cognitive Sciences, 2002
Research on infant cognition using habituation methods has sparked considerable controversy in recent years. At the core of the debates is the issue of whether infants have early (and possibly innate) conceptual understandings.
Sylvain Sirois, Denis Mareschal
exaly   +2 more sources