Results 241 to 250 of about 182,378 (305)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Sub-Anesthetic Ketamine Administration Decreases Deviance Detection Responses at the Cellular, Population- and Mesoscale Levels. [PDF]

Eur J Neurosci
Carreño-Muñoz MI, Ciancone Chama A, Chehrazi P, Chattopadhyaya B, Di Cristo G.   +4 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The dual impact of irrelevant visual onsets: Habituation of capture unlocks onset facilitation. [PDF]

Atten Percept Psychophys
Dissegna A, Betteto L, De Tommaso M, Turatto M.   +3 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Behaviour of ewes and lambs in response to human emotional odours. [PDF]

Sci Rep
Larrigaldie I, Damon F, Brimaud D, Lansade L, Schaal B, Destrez A.   +5 more
europepmc   +1 more source

Individual recognition in a jumping spider (<i>Phidippus regius</i>). [PDF]

Elife
Dahl CD, Cheng Y.
europepmc   +1 more source

Dual-Target SPG-Mandibular Neuromodulation for Post-Radiation Painful Trigeminal Neuropathy: A 7-Year Follow-up. [PDF]

Pain Rep
Tashlykov V, Morag O, Lichtenshtein G, Goor-Aryeh I, Brotfain E.   +4 more
europepmc   +1 more source

Identification of Neuroactive Chemicals in Crude Oil-Derived Water-Accommodated Fractions. [PDF]

Environ Sci Technol
Herold NK, So̷rensen L, Creese ME, Nahrgang J, Schweiger N, Tal T.   +5 more
europepmc   +1 more source

Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEε4 and Trem2*R47H. [PDF]

Front Aging Neurosci
Izydorczak M, Oumov M, Udhwani MV, Fostok F, Coronas-Samano G, Sanganahalli BG, Herman P, Hyder F, Verhagen JV.   +8 more
europepmc   +1 more source