Results 181 to 190 of about 152,602 (275)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Adaptive personalized federated learning with lightweight depthwise convolutional bottleneck network for novel intrusion detection system in internet of vehicles. [PDF]

Sci Rep
Almansour S, Yadav K, Alkwai LM, Alghamdi NS, Viriyasitavat W, Dhiman G.   +5 more
europepmc   +1 more source

Factors associated with: problems of using exploratory multivariable regression to identify causal risk factors. [PDF]

BMJ Med
Lewer D, Brothers T, O'Nions E, Pickavance J.   +3 more
europepmc   +1 more source

‘He Can Be Whatever He Wants to Be!?’: How Parents of a Child With a Disability Navigate Their Expectations for Their Child's Achievement and Success

Child &Family Social Work, EarlyView.
ABSTRACT Parents of children with disabilities (PCD) often struggle with a complex feelings comprised of joy and despair. On the one hand, they try to accept their child's disability; on the other hand, they fear that this acceptance may lower their aspirations for their child.
Menny Malka, Noga Rahat‐Drihem
wiley   +1 more source

A Statistical Analysis Plan Template for Observational Studies: Promoting Quality and Rigor in Research. [PDF]

J Stat Theory Pract
Watson HJ.
europepmc   +1 more source

Diverse Pathways and the Role of Timing: Youth Experiences of Leaving Care in China

Child &Family Social Work, EarlyView.
ABSTRACT In China, young people in state‐funded childcare institutions (Fuliyuan) are required to exit at age 18 unless still in education, compressing the move to adulthood. This study applies a life‐course lens to examine how the timing and sequencing of key life events shape care leavers' trajectories.
Shian Yin, Siobhan Laird, Lisa Warwick
wiley   +1 more source

Beyond the p Value Dichotomy: Alternatives for Statistical Inference-A Critical Review. [PDF]

J Eval Clin Pract
Ferreira MHL, Câmara LC, Junior NC.
europepmc   +1 more source

‘I like to dance with the flowers!’: Exploring the possibilities for biodiverse futures in an urban forest school

Children &Society, EarlyView.
Abstract This article explores the ways in which ‘forest school’, an educational approach where children engage in creative and play based activities in a ‘natural’ environment, can contribute towards Sustainable Development Goal 15 (SDG 15) by promoting sustainable use of terrestrial ecosystems and by helping address biodiversity loss. Drawing on data
Hannah Hogarth
wiley   +1 more source

Intercultural Cognitive Pragmatics as a tool for understanding autism. [PDF]

Front Hum Neurosci
Żuromski D, Pacholik-Żuromska A.
europepmc   +1 more source

Online Risk Behaviours Among Adolescents: Identifying Areas of Digital Vulnerability

Children &Society, EarlyView.
ABSTRACT As a period during which they undergo important physical, emotional and social changes, adolescence is of great importance for minors. In addition, adolescence is an initial stage in terms of children's use of their own mobile devices and their first access to the internet and social networks, an activity that becomes a generalised habit in ...
Sonia Carcelén‐García, Oliver Carrero Márquez, Myriam Durán Vilches   +2 more
wiley   +1 more source