Results 131 to 140 of about 69,077 (330)

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Comment on: "Transversus Thoracic Muscle Plane Block for Attenuating the Haemodynamic Response to Median Sternotomy". [PDF]

Turk J Anaesthesiol Reanim, 2023
Sethuraman RM.
europepmc   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Authors' Response: Comment on: "Transversus Thoracic Muscle Plane Block for Attenuating the Haemodynamic Response to Median Sternotomy". [PDF]

Turk J Anaesthesiol Reanim, 2023
Walian A, Magoon R, Shri I, Kashav RC.
europepmc   +1 more source

Comparison of two esmolol bolus doses on the haemodynamic response and seizure duration during electro-convulsive therapy [PDF]

, 1991
Anthony L. Kovac, Hiroshi Gotô, Manuel P. Pardo, Kasumi Arakawa   +3 more
openalex   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

Nebulised fentanyl, dexmedetomidine and magnesium sulphate for attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A double-blinded, randomised comparative study. [PDF]

Indian J Anaesth, 2023
Grover N, Taneja R, Rashid Y, Shrivastava N.   +3 more
europepmc   +1 more source

Multi-scale interaction of flow and the artery wall [PDF]

, 2009
We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying their widely separated spatial and temporal scales which participate.
2nd Micro and Nano Flows Conference (MNF2009), Atherton, MA, Care, CM, Collins, MW, Evans, D, Evans, PC, Halliday, I, Hose, DR, Khir, A, Krams, R, Lawford, PV, Lishchuk, SV, Ridger, V, Ventikos, Y, Walker, DC, Watton, PN   +15 more
core  

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source

Transversus Thoracic Muscle Plane Block for Attenuating the Haemodynamic Response to Median Sternotomy: A Case Series. [PDF]

Turk J Anaesthesiol Reanim, 2022
Walian A, Magoon R, Shri I, Kashav RC.
europepmc   +1 more source