Results 151 to 160 of about 212,248 (255)

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Association of Previous COVID-19 Infection and Preoperative Haemoglobin with Transfusion Burden and Early Postoperative Outcomes Following Cardiac Surgery with Cardiopulmonary Bypass. [PDF]

J Clin Med
Predoi CE, Filipescu D, Stefan MG, Filipescu R, Guz D, Margineanu C, Popescu M, Robu C, Bubenek-Turconi SI, Iordache N.   +9 more
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Predictors of low birth weight deliveries at a primary health care facility: Suhum Government Hospital, Ghana - a retrospective cross-sectional study. [PDF]

BMJ Public Health
Duah E, Lee Y, Han W, Osei KMO, Oh S, Aluma G, Konadu Asiedu EK, Akuoku M, Chun C, Badu K, Boateng SAA.   +10 more
europepmc   +1 more source

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

Advanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source

Admission haemoglobin and albumin as correlates of central nervous system inflammation in <i>rhodesiense human African trypanosomiasis</i> at Rumphi District Hospital, Malawi. [PDF]

J Public Health Afr
Nyirenda WT, Mapahla L, Dounebaine B, Dereje N, Nyasulu PS.   +4 more
europepmc   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Balancing Bulk Solution Chemistry and Cation Solvation for Stable Aqueous Aluminum Batteries

Advanced Science, EarlyView.
A dual‐scale electrolyte design balances bulk solution chemistry and cation solvation in aqueous aluminum batteries. Regulation of the bulk solution preserves high ionic conductivity and electrochemical stability, while modulation of the Al3+ solvation environment lowers desolvation penalties and suppresses hydrogen evolution. This balanced electrolyte
Bei‐Er Jia, Gang Wu, Huoliang Gu, Jin Jie Liew, Dongping Chen, Jinxuan Song, Dan‐Yang Wang, Erhai Hu, Hong Han Choo, Yuzhu Liu, Yue Hu, Jinpeng Song, Anchun Tang, Zhenxiang Xing, Qiang Zhu, Chunshuang Yan, Chade Lv, Man‐Fai Ng, Qingyu Yan   +18 more
wiley   +1 more source

Massive subchorionic thrombohaematoma (Breus' mole) causing postpartum haemorrhage: a case series and management strategy. [PDF]

Matern Health Neonatol Perinatol
Wang Y, Liu X, Chen Y, Tang M, Chen X.
europepmc   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source