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Immunity to Haemonchus contortus and Vaccine Development

2016
Sheep are capable of developing protective immunity to Haemonchus contortus through repeated exposure to this parasite, although this immune protection is the result of a complex interaction among age, gender, physiological status, pregnancy, lactation, nutrition and innate and adaptive immunity in the host animal.
Nisbet, A. J.   +3 more
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Inheritance of Cambendazole Resistance in Haemonchus contortus

American Journal of Veterinary Research, 1981
SUMMARY Fourth-molt larvae (M4) of cambendazole-resistant (CBZ-R) and cambendazole-susceptible (BPL) strains of Haemonchus contortus were recovered from donor lambs and inoculated orally into source lambs to effect mating in a 2nd lamb. Eggs produced by these parasitic matings were collected, cultured, and inoculated into lambs to compare the ...
H, Herlich, R S, Rew, M L, Colglazier
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Haemonchus contortus: Cloning and characterization of serpin

Experimental Parasitology, 2010
The serpin gene of Haemonchus contortus (hc-serpin) was cloned and characterized in this study. Specific primers for rapid amplification cDNA ends (RACE) were designed based on the expression sequence tag (EST, BM173953) to amplify the 3'- and 5'-ends of hc-serpin. The full length of the cDNA of this gene was obtained by overlapping the sequences of 3'-
Daosheng, Yi   +3 more
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Localisation of serotonin and dopamine in Haemonchus contortus

International Journal for Parasitology, 2011
Serotonin and dopamine play important roles in the biology of nematodes where they exert their effect on feeding, locomotion and reproductive behavior. Haemonchus contortus, a parasitic nematode which infects small ruminants, is responsible for considerable economic losses in agriculture.
Vijayaraghava T S, Rao   +3 more
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Carbohydrate epitopes on Haemonchus contortus antigens

Parasitology Research, 1996
Extracts of infective larvae and adults of the trichostrongylid Haemonchus contortus were studied for the presence of carbohydrate moieties. Several different lectin-binding sites were demonstrated in both stages using a panel of nine lectins. The carbohydrate specificity of the lectins used strongly suggests that alpha-D-mannose, alpha-D-glucose, and ...
Schallig, H. D., van Leeuwen, M. A.
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Haemonchus contortus resistance to monepantel in sheep

Veterinary Parasitology, 2015
In a sheep farm in the Netherlands with a suspected Haemonchus contortus resistance to monepantel (Zolvix®, Novartis Animal Health), a fecal egg count reduction test was carried out in two groups of lambs, according to the method of the World Association for the Advancement of Veterinary Parasitology.
R, Van den Brom   +3 more
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Detection of resistance to ivermectin in haemonchus contortus

International Journal for Parasitology, 1991
Infective, third-stage (L3) larvae of Haemonchus contortus isolates resistant to ivermectin (IVM) show a decreased sensitivity to IVM-induced paralysis in vitro. The inhibition of larval motility by IVM can be detected in L3 larvae incubated in the dark on an agar matrix containing IVM, by the failure of affected larvae to move when stimulated by ...
J H, Gill   +3 more
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Haemonchus contortus: The uptake and metabolism of closantel

International Journal for Parasitology, 1997
Closantel is an anthelmintic which associates with plasma albumin and is useful for the control of sheep parasites, such as Haemonchus contortus, that ingest blood. However, the utility of closantel for parasite control has been threatened by the emergence of resistance. The mechanisms of resistance are unknown.
Rothwell, J. T., Sangster, N.
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Hypergastrinaemia of sheep infected with Haemonchus contortus

Research in Veterinary Science, 1988
Radioimmunoassay of plasma gastrin has shown that a hypergastrinaemia occurs in yearling sheep, after infection with 10(6) infective third stage larvae of Haemonchus contortus. Plasma gastrin concentrations began to rise two to four days after infection, that is, at about the same time as, or slightly before, the abomasal pH was observed to increase.
C D, Nicholls   +4 more
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Development of a vaccine against haemonchus contortus

Parasitology Today, 1993
Haemonchus contortus is an economically important nematode parasite of sheep and the occurrence worldwide of strains resistant to anthelmintic chemicals has emphasized the need to develop a vaccine against it. Here, Ed Munn describes the approach to this problem adopted in his laboratory.
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