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Immunity to Haemonchus contortus and Vaccine Development
2016Sheep are capable of developing protective immunity to Haemonchus contortus through repeated exposure to this parasite, although this immune protection is the result of a complex interaction among age, gender, physiological status, pregnancy, lactation, nutrition and innate and adaptive immunity in the host animal.
Nisbet, A. J. +3 more
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Inheritance of Cambendazole Resistance in Haemonchus contortus
American Journal of Veterinary Research, 1981SUMMARY Fourth-molt larvae (M4) of cambendazole-resistant (CBZ-R) and cambendazole-susceptible (BPL) strains of Haemonchus contortus were recovered from donor lambs and inoculated orally into source lambs to effect mating in a 2nd lamb. Eggs produced by these parasitic matings were collected, cultured, and inoculated into lambs to compare the ...
H, Herlich, R S, Rew, M L, Colglazier
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Experimental Haemonchus contortus infections in guinea pigs
International Journal for Parasitology, 1989Approximately 40% of exsheathed Haemonchus contortus larvae administered to guinea pigs established in the stomach and developed into fourth stage larvae. Most worms were then lost between 5 and 7 days after infection and the guinea pigs were resistant to a second infection.
Wagland, B.M. +3 more
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Haemonchus contortus: Cloning and characterization of serpin
Experimental Parasitology, 2010The serpin gene of Haemonchus contortus (hc-serpin) was cloned and characterized in this study. Specific primers for rapid amplification cDNA ends (RACE) were designed based on the expression sequence tag (EST, BM173953) to amplify the 3'- and 5'-ends of hc-serpin. The full length of the cDNA of this gene was obtained by overlapping the sequences of 3'-
Daosheng, Yi +3 more
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Hypergastrinaemia of sheep infected with Haemonchus contortus
Research in Veterinary Science, 1988Radioimmunoassay of plasma gastrin has shown that a hypergastrinaemia occurs in yearling sheep, after infection with 10(6) infective third stage larvae of Haemonchus contortus. Plasma gastrin concentrations began to rise two to four days after infection, that is, at about the same time as, or slightly before, the abomasal pH was observed to increase.
C D, Nicholls +4 more
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Haemonchus contortus resistance to monepantel in sheep
Veterinary Parasitology, 2015In a sheep farm in the Netherlands with a suspected Haemonchus contortus resistance to monepantel (Zolvix®, Novartis Animal Health), a fecal egg count reduction test was carried out in two groups of lambs, according to the method of the World Association for the Advancement of Veterinary Parasitology.
R, Van den Brom +3 more
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Haemonchus contortus: Genetically determined polymorphism in females
Experimental Parasitology, 1971Abstract Studies were made on the genetic constitution of the different morphologic types of females of Haemonchus contortus. Strains with linguiform or knoblike females were crossed and the males of these strains were crossed also with smooth-bodied females. It was concluded that the morphologic diversity of the female H.
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Development of a vaccine against haemonchus contortus
Parasitology Today, 1993Haemonchus contortus is an economically important nematode parasite of sheep and the occurrence worldwide of strains resistant to anthelmintic chemicals has emphasized the need to develop a vaccine against it. Here, Ed Munn describes the approach to this problem adopted in his laboratory.
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