Results 21 to 30 of about 7,153 (69)

Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

Communications Biology, 2020
Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-specific traits among a wider group of ...
S. Doyle, A. Tracey, R. Laing, Nancy E. Holroyd, D. Bartley, Wojtek Bazant, H. Beasley, R. Beech, C. Britton, K. Brooks, U. Chaudhry, Kirsty Maitland, A. Martinelli, Jennifer D. Noonan, M. Paulini, M. Quail, E. Redman, Faye H Rodgers, G. Sallé, M. Shabbir, Geetha Sankaranarayanan, J. Wit, K. Howe, N. Sargison, E. Devaney, M. Berriman, J. Gilleard, J. Cotton   +27 more
semanticscholar   +1 more source

In Vitro Anthelmintic Activity of Crude Extracts of Artemisia herba-alba and Punica granatum against Haemonchus contortus

Journal of Parasitology Research, 2020
Gastrointestinal nematodes (GINs) are the major limiting factor for the successfulness of livestock production throughout the world. Emergence of resistance strains as well as scarcity and high cost of the currently available drugs has led to the ...
A. Ahmed, M. Ejo, T. Feyera, Dereje Regassa, Bahar Mummed, Solomon Assefa Huluka   +5 more
semanticscholar   +1 more source

New codon 198 β-tubulin polymorphisms in highly benzimidazole resistant Haemonchus contortus from goats in three different states in Sudan

Parasites & Vectors, 2020
Benzimidazole (BZ) resistance in gastrointestinal nematodes is a worldwide problem for livestock production, particularly in small ruminants. Assignment of the emergence of resistance using sensitive and reliable methods is required to adopt the correct ...
Khalid M. Mohammedsalih, J. Krücken, Amna E. Khalafalla, A. Bashar, Fathel-Rahman Juma, A. Abakar, Abdalhakaim A. H. Abdalmalaik, G. Coles, G. von Samson-Himmelstjerna   +8 more
semanticscholar   +1 more source

Advances in the Development of Anti-Haemonchus contortus Vaccines: Challenges, Opportunities, and Perspectives

Vaccines, 2020
The gastrointestinal nematode parasite Haemonchus contortus (H. contortus) is a resident of tropical and subtropical regions worldwide that imposes significant production losses, economic losses, and animal health issues in the small ruminant industry ...
Muhammad Ehsan, Rui-Si Hu, Qin-Li Liang, Jun-ling Hou, Xiaokai Song, Ruofeng Yan, Xing-Quan Zhu, Xiangrui Li   +7 more
semanticscholar   +1 more source

Isorhamnetin: A Nematocidal Flavonoid from Prosopis laevigata Leaves Against Haemonchus contortus Eggs and Larvae

Biomolecules, 2020
Haemonchus contortus affect small ruminants all over the world. Anthelmintics cause resistance, contamination, and a risk of public health. Prosopis laevigata is a plant used as a home remedy against many diseases in Mexico.
Edgar Jesús Delgado-Núñez, A. Zamilpa, M. González-Cortázar, A. Olmedo-Juárez, A. Cardoso-Taketa, Ernesto Sánchez‐Mendoza, D. Tapia‐Maruri, D. Salinas-Sánchez, P. Mendoza-de Gives   +8 more
semanticscholar   +1 more source

Cuminaldehyde induces oxidative stress-mediated physical damage and death of Haemonchus contortus.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Cuminaldehyde (CA), a monoterpenoid, preset in many plant sources including cumin, induces reactive oxygen-related damage and death in Haemonchus contortus, a parasitic worm with an LD50, values of 127.3 ± 7.5, 184.5 ± 12.1 and 104.1 ± 7.9 μg/mL for an ...
Vanshita Goel, L. Singla, Diptiman Choudhury   +2 more
semanticscholar   +1 more source

Ellagitannins Inhibit the Exsheathment of Haemonchus contortus and Trichostrongylus colubriformis Larvae: The Efficiency Increases Together with the Molecular Size

Journal of Agricultural and Food Chemistry, 2020
Worldwide, parasitic gastrointestinal nematodes continue to threaten animal health, welfare, and production in outdoor breeding systems of small ruminants.
M. Karonen, Jeffrey R. Ahern, L. Legroux, J. Suvanto, M. Engström, J. Sinkkonen, J. Salminen, H. Hoste   +7 more
semanticscholar   +1 more source

A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Haemonchus contortus is a critical parasite of goats and sheep. Infection by this blood-feeding gastrointestinal nematode (GIN) parasite has significant health consequences, especially in lambs and kids. The parasite has developed resistance to virtually
J. Sanders, Yue Xie, D. Gazzola, Hanchen Li, Ambily Abraham, K. Flanagan, F. Rus, Melanie Miller, Yan Hu, S. Guynn, Austin Draper, Sridhar Vakalapudi, K. Petersson, D. Zarlenga, Robert W. Li, J. Urban, G. Ostroff, A. Zajac, R. Aroian   +18 more
semanticscholar   +1 more source

Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins

Veterinary Research, 2020
Haemonchus contortus has evolved highly integrated and sophisticated mechanisms to promote coexistence with hosts. The excretory-secretory (ES) products generated by this parasite contribute to the regulation of the host immune response to facilitate ...
Mingmin Lu, Xiaowei Tian, Zhang Yang, Wenjuan Wang, Ai-Ling Tian, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li   +9 more
semanticscholar   +1 more source

Dynamic transcriptomic changes of goat abomasal mucosa in response to Haemonchus contortus infection

Veterinary Research, 2020
Gastrointestinal nematode (GIN) infections are one of the major constraints for grazing sheep and goat production worldwide. Genetic selection for resistant animals is a promising control strategy. Whole-transcriptome analysis via RNA-sequencing (RNA-seq)
Hadeer M. Aboshady, N. Mandonnet, Y. Félicité, Julien Hira, A. Fourcot, C. Barbier, Anna M. Johansson, E. Jonas, J. Bambou   +8 more
semanticscholar   +1 more source