Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test - Demonstrated in vitro and ex vivo. [PDF]
PLoS ONE, 2017 Canine models of severe haemophilia resemble their human equivalents both regarding clinical bleeding phenotype and response to treatment. Therefore pre-clinical studies in haemophilia dogs have allowed researchers to make valuable translational ...
Daniel Elenius Madsen +4 more
doaj +1 more source
Impact of Functional Disability on Quality of Life in Patients with Haemophilia: An Observational Study [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Haemophilia is a disease characterised by multiple episodes of spontaneous as well as traumatic bleeding leading to joint pains, joint damage.
Ashish Kavi +3 more
doaj +1 more source
Haemophilia A and haemophilia B: molecular insights [PDF]
Molecular Pathology, 2002 This review focuses on selected areas that should interest both the scientist and the clinician alike: polymorphisms within the factor VIII and factor IX genes, their linkage, and their ethnic variation; a general assessment of mutations within both genes and a detailed inspection of the molecular pathology of certain mutations to illustrate the ...
openaire +4 more sources
Evaluation of the Burden of Bone Fractures in People Living With Haemophilia: A Registry-Based Matched Cohort Study. [PDF]
HaemophiliaABSTRACT Background Bone diseases, such as low bone mineral density and osteoporosis is an emerging concern in people with haemophilia (PWH). As a consequence, PWH might experience fractures more frequently than the general population. Our primary aim was to compare the incidence of bone fractures in PWH and controls without bleeding disorders.
Germini F +6 more
europepmc +2 more sources
Global coagulation assays in hemophilia A: A comparison to conventional assays
Research and Practice in Thrombosis and Haemostasis, 2020 Background Global assays measure the interactions of coagulants, anticoagulants, and platelets on thrombin generation and may reflect the comprehensive coagulation potential in patients with hemophilia better than conventional assays.
Saman Aghighi +5 more
doaj +1 more source
Evolution of Haemophilia Care in Europe: 10 years of the principles of care
Orphanet Journal of Rare Diseases, 2020 Introduction The European principles of care in haemophilia marked their first decade in 2018. These guiding principles were the beginning of the European Haemophilia Consortium (EHC) review of countries’ adherence to these principles in 2009, 2012, 2015
D. Noone +4 more
doaj +1 more source
Evaluation of platelet function in thrombocytopenia
Platelets, 2018 Whole blood aggregometry is a functional assay for determination of platelet function. Until now, whole blood aggregometry has not been considered feasible at low platelet counts.
Mette Tiedemann Skipper +4 more
doaj +1 more source
Atypical Presenting Symptoms of Acute Onset Acquired Haemophilia with Eosinophilic Fasciitis
European Journal of Case Reports in Internal Medicine, 2020 Acquired haemophilia is a bleeding disorder caused by antibodies against coagulation factors. Some cases are associated with autoimmune diseases. However, no cases of acquired haemophilia with eosinophilic fasciitis have been previously reported.
Yuto Nakakubo +2 more
doaj +1 more source
The Journal of Haemophilia Practice, 2023 The European Haemophilia Consortium (EHC) Think Tank Workstream on Access Equity aims to identify and address the key challenges to ensuring access equity to healthcare services for people with rare diseases. In this context, access refers to the ability
Skouw-Rasmussen Naja, Savini Laura
doaj +1 more source
CATCH 2023 Meeting Summary: Collaborate & Address Treatment Challenges in Haemophilia
The Journal of Haemophilia PracticeAccess to treatment and healthcare services for people with haemophilia in the United Kingdom (UK) and Republic of Ireland ranks highly by international standards for contemporary haemophilia management.
Benson Gary +12 more
doaj +1 more source