Results 191 to 200 of about 18,669 (233)

Haemophilia B: Christmas disease

Expert Opinion on Pharmacotherapy, 2005
Haemophilia B is an inherited bleeding disorder associated with a deficiency of coagulation factor IX. The hallmark of the severe phenotype is recurrent and spontaneous bleeding into joints, which can lead to joint deformity and arthritis at an early age.
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Inhibitors in haemophilia B: the Italian experience

Haemophilia, 2013
SummaryThe prevalence of inhibitors in haemophilia B is significantly lower than that of patients with haemophilia A. However, the peculiar occurrence of allergic reactions associated with the onset of inhibitor in haemophilia B (HB) may render immune tolerance a risky procedure.
G, Castaman, E, Bonetti, M, Messina, M, Morfini, A, Rocino, F A, Scaraggi, G, Tagariello   +6 more
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Genetics and molecular biology of haemophilias A and B

Blood Coagulation & Fibrinolysis, 1991
The development of rapid procedures for the characterization of mutations is advancing the knowledge of the molecular biology of the haemophilias and transforming the strategies for the diagnoses required for genetic counselling. In haemophilia B more than 300 mutants have been fully characterized.
P M, Green, A J, Montandon, D R, Bentley, F, Giannelli   +3 more
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Homozygous Expression of Haemophilia B in a Heterozygote

Acta Medica Scandinavica, 1978
ABSTRACT. A case of clinically severe haemophilia B in a woman is described. In 1977 she was delivered of a healthy male child, showing that she is heterozygous for the haemophilia gene. This seems to be the first report of a proven heterozygote with the homozygous expression of severe haemophilia.
L, Holmberg, I M, Nilsson, P, Henriksson, K H, Orstavik   +3 more
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High frequency of HLA‐DR5 in Greek patients with haemophilia A and haemophilia B

Tissue Antigens, 1986
Sixty unrelated Greek patients with haemophilia (46 with haemophilia A and 14 with haemophilia B) were typed for HLA‐A, B and DR antigens. A highly significant increase in the frequency of HLA‐DR5 was observed in both groups of patients (58.6% vs 30.0%, χ2= 10.47, pc < 0.03, RR = 3.31 for haemophilia A and 78.5% vs 30.0%, χ2= 12.32, pc < 0.007 ...
C, Papasteriades, M, Varla, J, Economidou, K, Marcacis, C, Mitsouli, K, Louisou, T, Mandalaki, A, Roumeliotou, G, Papaevangelou   +8 more
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Eftrenonacog Alfa: A Review in Haemophilia B

Drugs, 2017
Eftrenonacog alfa (Alprolix™) is a recombinant fusion protein comprising human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 (i.e. rFIXFc). The presence of the Fc domain extends the terminal half-life (t½) of rFIXFc, permitting prolonged treatment intervals.
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Prospects for gene therapy of haemophilia A and B

British Medical Bulletin, 1995
Haemophilia A and B are relatively rare, X-linked inherited bleeding disorders which are life-threatening to patients unless treated by regular injections of factors VIII or IX, respectively. Gene therapy offers the prospect of a cure for the disease, thus potentially freeing patients from the existing regimens of regular intravenous injection of ...
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Another Genetic Variant of Haemophilia B: Haemophilia B Leyden

Scandinavian Journal of Haematology, 1970
J J, Veltkamp, J, Meilof, H G, Remmelts, D, van der Vlerk, E A, Loeliger   +4 more
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Genetic causes of haemophilia in women and girls

Haemophilia, 2021
Christopher Bean, Connie H. Miller
exaly  

[Haemophilia A and B in dogs].

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2013
Based on own clinical experiences and the literature, this review article elaborates on aspects of aetiology, pathogenesis, clinical signs, diagnosis and therapy of haemophilia A and B in dogs. When compared to humans, dogs reveal more severe haemorrhagic symptoms at a defined residual factor activity (e.g.
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