Results 291 to 300 of about 12,995,996 (318)

Haemophilia B: Christmas disease

Expert Opinion on Pharmacotherapy, 2005
Haemophilia B is an inherited bleeding disorder associated with a deficiency of coagulation factor IX. The hallmark of the severe phenotype is recurrent and spontaneous bleeding into joints, which can lead to joint deformity and arthritis at an early age.
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Inhibitors in haemophilia B: the Italian experience

Haemophilia, 2013
SummaryThe prevalence of inhibitors in haemophilia B is significantly lower than that of patients with haemophilia A. However, the peculiar occurrence of allergic reactions associated with the onset of inhibitor in haemophilia B (HB) may render immune tolerance a risky procedure.
E. Bonetti, M. Messina, F. A. Scaraggi, Giancarlo Castaman, Giuseppe Tagariello, Angiola Rocino, Massimo Morfini   +6 more
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Population and molecular-genetic aspects of Haemophilia A and Haemophilia B in Uzbekistan [PDF]

Cytology and Genetics, 2008
The present study summarizes results of retrospective epidemiological and molecular-genetic investigations of Haemophilia A and Haemophilia B in Uzbekistan. In the period from 1991 to 2004, a combined total of 1304 cases of Haemophilia A and Haemophilia B were recorded in the republic. The morbidity index varied from 0.75 to 1.46 per 10000 newborn male
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Genetics and molecular biology of haemophilias A and B

Blood Coagulation & Fibrinolysis, 1991
The development of rapid procedures for the characterization of mutations is advancing the knowledge of the molecular biology of the haemophilias and transforming the strategies for the diagnoses required for genetic counselling. In haemophilia B more than 300 mutants have been fully characterized.
D. R. Bentley, Peter M. Green, A. J. Montandon, Francesco Giannelli   +3 more
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Homozygous Expression of Haemophilia B in a Heterozygote

Acta Medica Scandinavica, 1978
ABSTRACT. A case of clinically severe haemophilia B in a woman is described. In 1977 she was delivered of a healthy male child, showing that she is heterozygous for the haemophilia gene. This seems to be the first report of a proven heterozygote with the homozygous expression of severe haemophilia.
Karen Helene Ørstavik, Inga Mane Nilsson, Per Henriksson, Lars Holmberg   +3 more
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Eftrenonacog Alfa: A Review in Haemophilia B

Drugs, 2017
Eftrenonacog alfa (Alprolix™) is a recombinant fusion protein comprising human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 (i.e. rFIXFc). The presence of the Fc domain extends the terminal half-life (t½) of rFIXFc, permitting prolonged treatment intervals.
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Another Genetic Variant of Haemophilia B: Haemophilia B Leyden

Scandinavian Journal of Haematology, 1970
J. J. Veltkamp, E. A. Loeliger, H. G. Remmelts, D. Vlerk, J. Meilof   +4 more
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Prospects for gene therapy of haemophilia A and B

British Medical Bulletin, 1995
Haemophilia A and B are relatively rare, X-linked inherited bleeding disorders which are life-threatening to patients unless treated by regular injections of factors VIII or IX, respectively. Gene therapy offers the prospect of a cure for the disease, thus potentially freeing patients from the existing regimens of regular intravenous injection of ...
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CpG POLYMORPHISMS AND HAEMOPHILIA B

The Lancet, 1989
P.R. Winship, Michael W. Gray
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Haemophilia B+ with Inhibitor

Thrombosis and Haemostasis, 1988
Rainer Schwaab, H Egli, H. H. Brackmann, Michael Ludwig, Klaus Olek   +4 more
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