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Haemophilus influenzae Type b Osteomyelitis

Archives of Pediatrics & Adolescent Medicine, 1978
Three children had osteomyelitis due to Haemophilus influenzae type b. They were seen with signs and symptoms indistinguishable from infection caused by other organisms. One child was initially misdiagnosed as having septic arthritis because of failure to appreciate that Hemophilus may also cause bone infection.
D M, Granoff, E, Sargent, D, Jolivette
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Haemophilus influenzae type b: the search for a vaccine

The Pediatric Infectious Disease Journal, 1987
In adults Hib CPS protein conjugates are much more immunogenic than the polysaccharide alone; further studies have shown that they induce a booster response in children. The antibodies produced in response to the conjugates have the same biologic properties, isotype and IgG subclass composition as those elicited by Hib CPS alone or those present in ...
J B, Robbins, R, Schneerson
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Haemophilus influenzae Type b

1991
Invasive disease caused by Haemophilus influenzae type b (Hib) is recognized as a leading infectious disease health problem, primarily for young children (Table 1). An estimated 20,000 persons develop invasive Hib disease each year in the United States, and it has also been estimated that during the first 5 years of life the cumulative incidence of ...
Stephen L. Cochi, Joel I. Ward
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Haemophilus influenzae type b disease in twins

The Journal of Pediatrics, 1983
B. catarrhalis is detected by the rapid acidometric assay only after prolonged periods of incubation (30 to 60 minutes) with penicillin, 7 in contrast to the almost immediate detection of the 13-1actamase of H. influenzae. This finding indicates that the/3-1actamase is present in small amounts, is "inducible," or as Doern et al.
S L, Kaplan, E O, Mason
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Haemophilus Influenza Type b

Disease-a-Month, 2007
Susan Shoshana Weisberg, MD, FCP, FAAP aemophilus influenza type b is best known by its nickname, Hib. The influenza” in Hib’s formal name is actually a mistake. The Hib germ was rst discovered in 1892, in the middle of a flu epidemic, and it was first solated from the saliva of patients suffering from influenza.
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Recombinant Porin of Haemophilus influenzae Type b

Journal of Infectious Diseases, 1992
A protein of approximately 40 kDa in the outer membrane of Haemophilus influenzae type b (Hib) behaves as a porin and permits transmembrane diffusion of low-molecular-weight solutes. The gene for Hib porin was cloned from an M13 library of chromosomal DNA of Hib strain ATCC9795.
J W, Coulton, A C, Chin, V, Vachon
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A decline in Haemophilus influenzae type b meningitis

The Journal of Pediatrics, 1993
During the past 50 years, there has been an unexplained fourfold increase in admissions for Haemophilus influenzae type b meningitis to the Children's Hospital of Pittsburgh, and an equally striking decline that cannot be attributed entirely to immunization.
R H, Michaels, O, Ali
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Haemophilus influenzae Type b Infections in Adults

Scandinavian Journal of Infectious Diseases, 1989
31 cases of invasive Haemophilus influenzae type b infections occurred in adults in Denmark during a period of 2 years and 5 months corresponding to an incidence of 0.3/100,000/year. Only 6 patients had no underlying condition. The incidence of H. influenzae type b infections in adults will probably rise in the future, because the increasing use of ...
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Haemophilus influenzae Type b Conjugate Vaccines

1995
In summary, all of the Hib conjugate vaccines are highly immunogenic and efficacious in children older than 12-15 months of age, and HbOC, PRP-OMPC, and PRP-T are highly immunogenic and demonstrated to be efficacious in infants as young as 2 months old.
P J, Kniskern, S, Marburg, R W, Ellis
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Haemophilus influenzae type b conjugate vaccine

Journal of Pediatric Health Care, 1988
Abstract Hib conjugate vaccine was developed with the ultimate goal of providing an effective vaccine for infants and younger children. The conjugate vaccine is as safe as Hib polysaccharide vaccine and significantly more immunogenic. Because antibody production after vaccination with conjugate vaccine in children 18 months of age or older is ...
J J, Campion, D T, Casto
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