Results 211 to 220 of about 563,227 (279)

Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective The ketogenic diet (KD) is a high‐fat, low‐carbohydrate intervention widely used to treat drug‐resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota‐dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with ...
Casey H. Meili   +4 more
wiley   +1 more source

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch   +5 more
wiley   +1 more source

Functional and molecular diversity of human C-fibers in pain modulation. [PDF]

open access: yesCurr Opin Support Palliat Care
Barakat A   +4 more
europepmc   +1 more source

An Intensity Measure‐Based Methodology for Ground Motion Orientation in Seismic Structural Assessment

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT In current dynamic time history assessment protocols, ground motion recordings are mostly oriented along fixed sensor directions. Consequently, the orientation of the principal resultant of rupture energy, which may control the maximum structural demand, remains undefined, precluding consistent correlation with physically detrimental ...
Santiago Londono‐Lopez   +4 more
wiley   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

open access: yesExploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma   +13 more
wiley   +1 more source

Under‐Explored Species, Breeds and Cell Types With Potential for Cultivated Meat Production

open access: yesFood Bioengineering, EarlyView.
This graphical abstract illustrates how the strategic selection of overlooked cell lines from novel species and specific agricultural breeds can help overcome current manufacturing bottlenecks in cultivated meat production. The schematic links the concept of an ‘ideal cell line’ to four key bioprocessing and product advantages that can be optimised ...
William Gordon‐Petrovskii   +6 more
wiley   +1 more source

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