Results 121 to 130 of about 429,150 (378)

Histopathology of aging of the hair follicle

Journal of cutaneous pathology, 2019
Hair follicles experience several changes with aging, the most noticeable of which is graying of the hair shaft due to loss of melanin. Additional changes in the diameter and length of the hair have contributed to the concept of senescent alopecia, which
A. Fernandez-Flores, M. Saeb-Lima, D. Cassarino   +2 more
semanticscholar   +1 more source

Exploring differentially expressed genes by RNA-Seq in cashmere goat (Capra hircus) skin during hair follicle development and cycling. [PDF]

PLoS ONE, 2013
Cashmere goat (Capra hircus) hair follicle development and cycling can be divided into three stages: anagen, catagen and telogen. To elucidate the genes involved in hair follicle development and cycling in cashmere goats, transcriptome profiling of skin ...
Rongqing Geng, Chao Yuan, Yulin Chen
doaj   +1 more source

Wonders of Harbor and Grey Seal Whiskers: Morphology, Natural Frequencies, and 3D Modeling

Advanced Science, EarlyView.
Seals detect prey by sensing vortices using whiskers. How whisker morphologies and locations respond to hydrodynamic signals across various frequencies remains unclear. This study measures whiskers’ natural frequencies and morphologies and maps them to whisker locations on the muzzle, providing insights into how seals interpret hydrodynamic signals ...
Xingwen Zheng, Amar M. Kamat, Ming Cao, Michael S. Triantafyllou, Ajay Giri Prakash Kottapalli   +4 more
wiley   +1 more source

Hierarchical patterning modes orchestrate hair follicle morphogenesis

PLoS Biology, 2017
Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing reaction–diffusion system posits that interacting diffusible signals produced by static cells first define a ...
James D. Glover, K. Wells, F. Matthäus, K. Painter, William K W Ho, Jon Riddell, Jeanette A. Johansson, M. Ford, C. Jahoda, V. Klika, R. Mort, D. Headon   +11 more
semanticscholar   +1 more source

Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage [PDF]

, 2004
Estrogen receptor ligands are important modulators of skin physiology and are involved in the control of normal hair follicle cycling. Here, we have studied the effects of topically applied 17-β-estradiol on pathologic hair follicle cycling as seen ...
Handjiski, Bori, Ohnemus, Ulrich, Paus, Ralf, ünalan, Murat   +3 more
core   +1 more source

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

Advanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu   +3 more
wiley   +1 more source

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Nature Communications, 2017
Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the ...
Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, M. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huan-huan Jia, Yu'e Wu, Jia Liu, S. Nedospasov, E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu   +24 more
semanticscholar   +1 more source

Prolactin delays hair regrowth in mice [PDF]

, 2006
Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in ...
Ashby, M.G., Blazek, K., Craven, A.J., Nixon, A.J., Ormandy, C.J., Pearson, A.J., Wilkins, Richard J.   +6 more
core   +2 more sources

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. [PDF]

, 2011
The vitamin D receptor (VDR) ligand, 1,25 dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), reduces proliferation and enhances differentiation, and thus has been investigated for a role in preventing or treating cancer.
Bikle, Daniel D, Elalieh, Hashem, Elias, Peter M, Teichert, Arnaud E, Welsh, JoEllen   +4 more
core   +6 more sources