Results 61 to 70 of about 2,575,346 (386)

Pharmacology of testosterone replacement therapy preparations

Translational Andrology and Urology, 2016
The goal of testosterone replacement therapy (TRT) is to return serum testosterone levels to within physiologic range and improve symptoms in hypogonadal men.
J. Shoskes, M. Wilson, M. Spinner
semanticscholar   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons

JID Innovations, 2022
Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are primary, lymphocytic cicatricial hair loss disorders. These model epithelial stem cell (SC) diseases are thought to result from a CD8+ T-cell‒dominated immune attack on the hair follicle (
Maryanne Makredes Senna, Erik Peterson, Ivan Jozic, Jérémy Chéret, Ralf Paus   +4 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

Clinical, Cosmetic and Investigational Dermatology, 2021
Yun-Ho Choi, Jae Young Shin, Jaeyoon Kim, Nae-Gyu Kang, Sanghwa Lee LG Household & Health Care (LG H&H) R&D Center, Seoul, 07795, KoreaCorrespondence: Sanghwa LeeLG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul ...
Choi YH, Shin JY, Kim J, Kang NG, Lee S
doaj  

Bioavailable silicon forms in dietary supplements [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2020
Silicon (Si) is an element necessary for the proper functioning of the body. It affects cell viability, osteoblast differentiation, blood vessel elasticity, type I collagen synthesis, as well as the condition of the skin, hair, and nails.
Paulina Putko, Mirosław Kwaśny
doaj   +1 more source

Jojoba Oil: An Updated Comprehensive Review on Chemistry, Pharmaceutical Uses, and Toxicity

Polymers, 2021
Jojoba is a widely used medicinal plant that is cultivated worldwide. Its seeds and oil have a long history of use in folklore to treat various ailments, such as skin and scalp disorders, superficial wounds, sore throat, obesity, and cancer; for ...
Heba A. Gad, A. Roberts, S. H. Hamzi, Haidy A. Gad, Ilham Touiss, A. Altyar, O. Kensara, M. Ashour   +7 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Traditional uses and phytochemical constituents of Cynanchum otophyllum C. K. Schneid (Qingyangshen)

World Journal of Traditional Chinese Medicine, 2023
The roots of the plant Cynanchum otophyllum C. K. Schneid (Apocynaceae), known as Qingyangshen in Chinese, are used for a long time as a traditional medicine by different ethnic communities in the Yunnan province (China).
Christian Bailly, Cheng Xiang, Ji-Hong Zhang   +2 more
doaj   +1 more source

Evaluation And Preparation of Herbal Hair Oil

, 2023
Hair plays an important role in human behavior We use many cosmetics to improve our hair. Herbal preparations always work, they have little or no side effects compared to synthetic products. This study focuses on the importance of herbal hair oil in treating hair problems such as baldness, alopecia, hair loss, gray hair, dryness and dandruff in general.
openaire   +1 more source