Results 1 to 10 of about 11,605 (196)

Hairy cell leukemia and pregnancy [PDF]

Терапевтический архив, 2017
The paper presents experience in following up and treating hairy cell leukemia (HCL) during pregnancy. The combination of HCL and pregnancy was observed in 5 patients. The patients’ median age was 35 years (range, 28—42 years).
L S Al-radi, T N Moiseeva, S Yu Smirnova, R G Shmakov   +3 more
doaj   +3 more sources

Plasma cell leukemia mimicking hairy cell leukemia

Hematology/Oncology and Stem Cell Therapy, 2015
A42-year-old female presented with fever and shortness of breath, and was diagnosed with community acquired pneumonia. On presentation she was found to have a white cell count of 13 · 10/L, hemoglobin of 7.1 g/dL and platelets of 51 · 10/L. Peripheral blood smear showed left shift and many cells with hairy projections (56%) (See Fig.
Amr Hanbali, Abdulaziz Alrajeh, Walid Rasheed   +2 more
doaj   +3 more sources

BRAF mutation in hairy cell leukemia

Oncology Reviews, 2014
BRAF is a serine/threonine kinase with a regulatory role in the mitogen-activated protein kinase (MAPK) signaling pathway. A mutation in the RAF gene, especially in BRAF protein, leads to an increased stimulation of this cascade, causing uncontrolled ...
Ahmad Ahmadzadeh, Saeid Shahrabi, Kaveh Jaseb, Fatemeh Norozi, Mohammad Shahjahani, Tina Vosoughi, Saeideh Hajizamani, Najmaldin Saki   +7 more
doaj   +3 more sources

Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report

Biomedical Papers, 2023
Background. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections.
Dominika Ecsiova, Katerina Kamaradova, Marketa Nova, Petr Hoffmann, Petra Rozsivalova, Martin Simkovic, Pavel Zak   +6 more
doaj   +1 more source

The Detection of BRAF-V600E Mutation in Hairy Cell Leukaemia by Polymerase Chain Reaction and Study of its associated Clinicohaematological Parameters

Pakistan Armed Forces Medical Journal, 2022
Objective: To contemplate the occurrence of a rare mutation (BRAF V600E) in the patients having Hairy cell leukemia in our setting, which wouldserve asuseful analytic and diagnostic criteria. Study Design: Analytical cross sectional study.
Muhammad Ijaz Iqbal, Helen Mary Robert, Nabeela Khan, Rafia Mahmood, Ayesha Khurshid, Saleem Ahmed Khan   +5 more
doaj   +1 more source

Case report: A case of classic hairy cell leukemia with CNS involvement treated with vemurafenib

Frontiers in Oncology, 2023
Hairy cell leukemia (HCL) is a rare mature B-cell lymphoproliferative disorder and most often presents as classic hairy cell leukemia. This entity is characterized by an indolent course and the presence of the BRAF V600E mutation.
Anna E. Johnson, Athul Raj Raju, Aasems Jacob, Gerhard C. Hildebrandt   +3 more
doaj   +1 more source

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

Haematologica, 2013
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable
Enrico Tiacci, Gianluca Schiavoni, Maria Paola Martelli, Emanuela Boveri, Roberta Pacini, Alessia Tabarrini, Silvia Zibellini, Alessia Santi, Valentina Pettirossi, Elisabetta Fortini, Stefano Ascani, Luca Arcaini, Giorgio Inghirami, Marco Paulli, Brunangelo Falini   +14 more
doaj   +1 more source

Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia

Haematologica, 2008
Background We previously reported ongoing mutational and isotype switch events in the immunoglobulin (Ig) heavy chain (H) locus in hairy cell leukemia.
Francesco Forconi, Elisa Sozzi, Davide Rossi, Surinder S. Sahota, Teresa Amato, Donatella Raspadori, Livio Trentin, Lorenzo Leoncini, Gianluca Gaidano, Francesco Lauria   +9 more
doaj   +1 more source

Recent advances in understanding and managing hairy cell leukemia [version 1; referees: 4 approved]

F1000Research, 2018
Hairy cell leukemia is a rare B-cell malignancy that is characterized by an indolent course. It was initially described as a distinct entity in 1958. Before the establishment of modern treatment, median survival was only 4 years.
Tobias Roider, Brunangelo Falini, Sascha Dietrich   +2 more
doaj   +1 more source

Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature

MGM Journal of Medical Sciences, 2023
Hairy cell leukemia (HCL), an uncommon cancer affecting B-lymphocytes primarily in the bone marrow and spleen, is identified by abnormal projections on malignant B cells, which give the illness its name.
Adwaita Mashelkarm, Shirish Khatu, Prakash Dive, S Sudhamani   +3 more
doaj   +1 more source