Results 91 to 100 of about 22,302 (228)
Laparoscopic Splenectomy for Hairy Cell Leukemia in Pregnancy
Case Reports in Medicine, 2010 Objective. We present a successful case of laparoscopic splenectomy for a massively enlarged spleen at 25 weeks of gestation for hairy cell leukemia in pregnancy in a woman with initial hemoglobin of 4.3 gm/dl and platelet count of 18,000/mm3.
Beni Adegoke Adeniji +5 more
doaj +1 more source
BRAF mutation in hairy cell leukemia
Oncology Reviews, 2014 BRAF is a serine/threonine kinase with a regulatory role in the mitogen-activated protein kinase (MAPK) signaling pathway. A mutation in the RAF gene, especially in BRAF protein, leads to an increased stimulation of this cascade, causing uncontrolled ...
Ahmad Ahmadzadeh +7 more
doaj +1 more source
Clinical Genetics, EarlyView.Comprehensive clinical description of 12 subjects with pathogenic PRKAR1B variants, including two heterozygous deletions supporting haploinsufficiency as a possible mechanism of disease, providing valuable insight into the pathophysiology of MASNS and setting a framework upon which to design future mechanistic studies of PKA signaling in brain ...
Sebastian Burkart +17 more
wiley +1 more source
HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1 [PDF]
, 2019 An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa.
Al-Saleem, Jacob +6 more
core +3 more sources
The FEBS Journal, EarlyView.Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to genetic mutations that occur within the negative regulatory region of the Notch 1 gene is linked to the development of ...
Gerard F Hoyne
wiley +1 more source
Listeria monocytogenes Infection in Hairy Cell Leukemia: A Case Report and Literature Review
Case Reports in Hematology, 2018 Listeria monocytogenes infections have been described in patients with diverse types of malignancy, especially leukemia. We report the case of a 65-year-old man with previously untreated hairy cell leukemia characterized by CD5 positivity and trisomy 12 (
James C. Barton, Hayward S. Edmunds
doaj +1 more source
Characterization and automatic screening of reactive and abnormal neoplastic B lymphoid cells from peripheral blood [PDF]
, 2016 The objective was to advance in the automatic, image-based, characterization and recognition of a heterogeneous set of lymphoid cells from peripheral blood, including normal, reactive, and five groups of abnormal lymphocytes: hairy cells, mantle cells ...
Alférez Baquero, Edwin Santiago +3 more
core +2 more sources
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Point‐of‐care testing (POCT) for hematology enables clinicians to access actionable results during patient visits, supporting timely decisions such as transfusions or chemotherapy adjustments. However, POCT analyzers must demonstrate clinical performance comparable to centralized laboratory systems. We conducted a proof‐of‐concept
Ryan C. Shean, Sterling T. Bennett
wiley +1 more source
Humphrey Center News: Winter 1990 v. 5, no. 2 [PDF]
, 1990 Newsletter of the Hubert H.
Anthony, Richard P. +1 more
core
Immunology, EarlyView.Eight percent of this cohort of patients had a latent Neoehrlichia mikurensis infection. It was only the latently infected patients who had N. mikurensis‐specific T cells, not the matched B‐cell lymphoma patients without the infection. The T‐cell responses of latently infected patients included perforin‐expressing Th1 and CD8+ T cells that upregulated ...
Linda Wass +4 more
wiley +1 more source