Results 111 to 120 of about 22,302 (228)

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 661-672, March 2026.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

Hairy cell leukemia: A retrospective study on 11 patients in the Western of Iran

International Journal of Hematology-Oncology and Stem Cell Research, 2015
Background: Hairy cell leukemia (HCL) is a chronic B-cell lymphoid leukemia characterized by pancytopenia, splenomegaly, myelofibrosis and the presence in peripheral blood, bone marrow and spleen of atypical lymphoid cells with a hairy aspect.
Mehrdad Payandeh, Masoud Sadeghi, Edris Sadeghi   +2 more
doaj  

Multimodal Image Analysis of Chronic Leukemic Lymphoproliferative Disorders and the Hypothesis of »Single« and »Multiple« Programmed Stops in the Development of Typical and Atypical Forms of Leukemias and Lymphomas [PDF]

, 2010
The study consisted of morphometric analysis, assessment of the argyrophilic nucleolar organization region (AgNOR) characteristics, and image cytometry (ICM) in different tumor mass compartments: bone marrow (BM), peripheral blood (PB) and lymph nodes ...
Biljana Jelić Puškarić, Branimr Jakšić, Delfa Radić-Krišto, Ika Kardum-Skelin, Matko Kardum, Ozren Jakšić   +5 more
core   +2 more sources

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N. Vasishth, Evan Y. Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa   +9 more
wiley   +1 more source

The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen‐presenting cells shape the T cell repertoire, recent discoveries unveil a far richer cellular landscape that challenges long‐held views of thymus structure and function. This review traces the history of early
Roberta Ragazzini, Paola Bonfanti
wiley   +1 more source

Skeletal involvement of hairy cell leukemia

Clinical Case Reports, 2018
Key Clinical Message Hairy cell leukemia (HCL) is a rare B‐cell lymphoproliferative disorder. Skeletal involvement is an unusual manifestation of HCL, complicating the course of the disease in approximately 3% of patients.
Eric Durot, Anne Quinquenel, Jean‐Charles Kleiber, Martine Patey, Arnaud Bazin, Alain Delmer   +5 more
doaj   +1 more source

Rare Germline Variants in CDKN2A‐Negative Children and Adolescents With Cutaneous Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 2, March 2026.
Individuals with childhood and adolescent melanoma carry inherited mutations in shelterin complex genes, pigmentation genes and MBD4, but have fewer MC1R R‐alleles than adults with melanoma. Created with BioRender.com. ABSTRACT Cutaneous melanoma is a complex disease influenced by both environmental and genetic factors. Inherited susceptibility plays a
Peter A. Johansson, Jane M. Palmer, Linh T. Bui‐Raborn, Mai Xu, Kristine M. Jones, Herbert Higson, Jia Liu, Kelly M. Brooks, Antonia L. Pritchard, Nicholas K. Hayward, Kevin M. Brown   +10 more
wiley   +1 more source

Mosaic Li Fraumeni Syndrome Not Identified in Germinal Tissue

Molecular Genetics &Genomic Medicine, Volume 14, Issue 2, February 2026.
In this study, we presented the first clinical case report of mosaic Li Fraumeni syndrome eluding germinal tissue. This case highlights the complexity of interpreting mosaic variants in TP53, and the difficulty in relaying cancer and reproductive risk information in the context of mosaic Li Fraumeni syndrome.
Rhianna M. Urban, Nisha Kanwar, Megan A. Holdren, Megan F. Hoenig, Laura M. Rust, Myra J. Wick, Matthew J. Ferber, Zhiyv Niu, Sounak Gupta, Wei Shen   +9 more
wiley   +1 more source

Hyalohyphomycotic chronic rhinosinusitis caused by Microascus cirrosus in a cat

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 13‐year‐old, male, neutered, indoor‐only, domestic long‐haired cat was presented with an 8‐month history of sneezing and a 2‐month history of epistaxis. Computed tomography demonstrated an irregular contrast‐enhancing soft tissue opacity within both nasal cavities and osteolysis of surrounding bony structures.
Leonel Frutuoso, Samuel Fowlie, Sean Haugland, Emma Corbett, Christopher Scudder   +4 more
wiley   +1 more source