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Immunophenotype of hairy‐cell leukemia
European Journal of Haematology, 199015 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10‐, CD19+, CD20+, CD21‐, CD22+, CD37+, CD38‐, FMC7+, LN1+, PCA‐1+, BLy7+and CD5‐).
I B, Hassan, H, Hagberg, C, Sundström
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Macroglobulinemia and Hairy-Cell Leukemia
New England Journal of Medicine, 1977Leukemic reticuloendotheliosis, or hairy-cell leukemia, is a distinct clinical entity characterized by the proliferation of cells that have prominent cytoplasmic projections and contain the tartrate-resistant isozyme 5 of acid phosphatase.1 2 3 Although the clinical and morphologic features of this disease are widely known, there is considerable ...
D W, Golde, A, Saxon, R H, Stevens
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Treatment of hairy-cell leukemia
Blood Reviews, 1990Hairy-cell leukemia is an unusual chronic lymphoid leukemia with distinctive clinical and pathological features. The management of this disorder has been revolutionized in the last decade with the discovery of the efficacy of alpha interferon and the inhibitors of adenosine metabolism, deoxycoformycin and chlorodeoxyadenosine.
M C, Lill, D W, Golde
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Chemoimmunotherapy for hairy cell leukemia
Best Practice & Research Clinical Haematology, 2015Success in the treatment of patients with hairy cell leukemia (HCL) over the last several decades is largely due to the high efficacy of the nucleoside analogs, cladribine and pentostatin. However, the relapse-free survival curves have not shown a plateau and many patients treated with these agents will eventually relapse. Although better understanding
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Vasculitides in hairy cell leukemia
Seminars in Arthritis and Rheumatism, 1995Forty-two cases of vasculitis coincident with hairy cell leukemia (HCL) have been reported, of which 17 had panarteritis nodosa (PAN), 21 had cutaneous leukocytoclastic vasculitis (LCV), and 4 had vessel wall infiltration by hairy cells. PAN generally occurred after the diagnosis of HCL, splenectomy, and infection.
P, Hasler, H, Kistler, H, Gerber
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The Biology of Hairy Cell Leukemia
Leukemia & Lymphoma, 2009As in all malignancies, the biology of HCL reflects both the behaviour of the malignant cells (hairy cells) themselves and their two-way interaction with the microenvironment. However, the tissue interactions of HCs are particularly striking and involve extensive remodelling of bone marrow, spleen and liver, with relative sparing of lymph nodes.
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Hairy cell leukemia and the microenvironment
Leukemia & Lymphoma, 2011Two-way interactions between HCs and the microenvironment are especially prominent in HCL. Many of these interactions are now reasonably well understood and are summarised in this article.
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Hairy Cell Leukemia in Father and Son
Medical Oncology, 2003Hairy cell leukemia (HCL) is an uncommon B cell disorder, and familial HCL is rarely encountered among the first degree relatives of HCL patients. A father and son, both of whom developed hairy cell leukemia, is presented in this report. The HLA haplotype shared by the father and son was A2, B18, BW6, CW7, DR3, DR10, and DQ8.
Mustafa, Cetiner +6 more
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Therapy of Hairy-Cell Leukemia
New England Journal of Medicine, 1982Hairy-cell leukemia is a well-defined disorder characterized by splenomegaly, pancytopenia, and morphologically typical neoplastic mononuclear cells in the blood and bone marrow. Since the description of this disease as leukemic reticuloendotheliosis by Bouroncle et al. in 1958,1 there has been considerable controversy regarding the cell line of origin
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Current treatment options in hairy cell leukemia and hairy cell leukemia variant
Cancer Treatment Reviews, 2006Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia and circulating lymphocytes displaying prominent cytoplasmic projections. HCL has usually an indolent course and the patients with asymptomatic disease do not require therapy. Treatment of progressive symptomatic HCL includes a variety
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