Results 131 to 140 of about 8,886,396 (384)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The early anaemia of Premature infants: The haemoglobin level of immature babies in the first half-year of life and the effect during the first three months of blood injections and iron therapy [PDF]

, 1935
Helen Mackay
openalex   +1 more source

Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters

BioDrugs, 2015
The purpose of making a “biobetter” biologic is to improve on the salient characteristics of a known biologic for which there is, minimally, clinical proof of concept or, maximally, marketed product data.
W. Strohl
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comment on "Precise half-life values for two-neutrino double beta decay"

, 2010
The results by A.S. Barabash [Phys. Rev. {\bf C 81}, 035501 (2010)] are shown to be incomplete. Tellurium data sets were reanalyzed using the best practices of ENSDF evaluations.
Pritychenko, B.
core   +1 more source

Does Matter have a Half-Life? [PDF]

, 1962
E. R. Swart
openalex   +3 more sources

The half-life of the first excited state of 111Cd [PDF]

, 1955
L.H.Th. Rietjens, H.J. van den Bold, A. Heyligers   +2 more
openalex   +1 more source

Safety and efficacy of BAY 94‐9027, a prolonged‐half‐life factor VIII

Journal of Thrombosis and Haemostasis, 2017
Essentials Recombinant factor VIII BAY 94‐9027 conjugates in a site‐specific manner with polyethylene glycol. BAY 94‐9027 was given to patients with severe hemophilia A as prophylaxis and to treat bleeds. BAY 94‐9027 prevented bleeds at dose intervals up
M. Reding, Heng Joo Ng, L. Poulsen, M. E. Eyster, Ingrid Pabinger, H. J. Shin, R. Walsch, Michael Marcel Lederman, Maria Wang, M. Hardtke, Lisa A. Michaels   +10 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Electron capture half-life of 243Cm [PDF]

, 1958
Gregory R. Choppin, S.G. Thompson
openalex   +1 more source