Results 131 to 140 of about 1,735,367 (287)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Bioavailability and remineralization rates of sediment-derived dissolved organic carbon from a Baltic Sea depositional area

Frontiers in Marine Science
This pilot study investigated the bioavailability and remineralization kinetics of the sediment-derived dissolved organic carbon (DOC) from the Gdańsk Deep, a depositional area in the Baltic Sea.
Monika Lengier, Katarzyna Koziorowska-Makuch, Beata Szymczycha, Karol Kuliński   +3 more
doaj   +1 more source

Quantifying the half-life of deviations from PPP: The role of economic priors [PDF]

The half-life of deviations from purchasing power parity (PPP) plays a central role in the ongoing debate about the ability of macroeconomic models to account for the time series behavior of the real exchange rate.
Lutz Kilian, Tao Zha
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Comparison of Combined Dissipation Behaviors and Dietary Risk Assessments of Thiamethoxam, Bifenthrin, Dinotefuran, and Their Mixtures in Tea

Foods
In the tea-planting process, insecticides are commonly combined, potentially prolonging the pre-harvest interval and heightening the risk of dietary exposure.
Tiancai Wang, Yongzhong Qian, Jieqiong Wang, Xueyan Yin, Qifu Liang, Guangqin Liao, Xiabing Li, Jing Qiu, Yanyang Xu   +8 more
doaj   +1 more source

Bright Half Life Assistant Director [PDF]

, 2018
My Theatre Arts thesis project was working as an assistant director (AD) on the play “Bright Half Life,” alongside my director/professor, Dana Resnick.
Lawver, Charles
core   +1 more source

Purification and characterization of a thermophilic NAD+‐dependent lactate dehydrogenase from Moorella thermoacetica

FEBS Open Bio, EarlyView.
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley   +1 more source

Estimating Advertising Half-Life and the Data Interval Bias. [PDF]

We compare three methods of estimating the duration, or half-life, of how well each method works with the data aggregated over different time intervals. In contrast with the existing theory on the, so called, data interval bias, our experiments are based
Broadbent, S., Dixon, J.M., Fry, T.R.L.
core  

Feasibility study of the observation of the neutrino accompanied double beta-decay of Ge-76 to the 0+(1) excited state of Se-76 using segmented germanium detectors [PDF]

, 2007
Neutrino accompanied double beta-decay of Ge-76 can populate the ground state and the excited states of Se-76. While the decay to the ground state has been observed with a half-life of 1.74 +0.18 -0.16 10^21 years, decays to the excited states have not ...
Kroeninger, K., Pandola, L., Tretyak, V.
core   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source