Results 161 to 170 of about 1,585,431 (199)

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Enhanced α2-3-linked sialylation determines the extended half-life of CHO-rVWF.

Blood
Byrne C, Ward S, O'Sullivan J, Chion A, Lopes P, Baci B, Dowd C, Jordan D, Baker R, Preston RJS, Monopoli M, Turecek PL, Kotsias M, Cheeseman J, Moran AB, Gardner RA, Spencer DIR, Atiq F, O'Donnell JS.   +18 more
europepmc   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Sub-epsilon natural ²³⁴U/²³⁸U measurements refine the ²³⁴U half-life and U-Th geochronology. [PDF]

Sci Adv
Hu HM, Shen CC, Cheng H, Woodhead JD, Edwards RL, Zhao JX, Huang CY, Lu PY, Chien WY, Wang J, Jia X, Yokoyama Y, Cai Y, Zachariáš J.   +13 more
europepmc   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model. [PDF]

Redox Biol
Sharma N, Bhat SH, Chaudhary S, Mathew B, Pandey S, Yadav S, Yadav M, Bindal V, Tripathi G, Sharma N, Sharma V, Gupta A, Nanda R, Kumari A, Sharma S, Maras JS.   +15 more
europepmc   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues. [PDF]

J Vet Res
Burmańczuk A, Osypiuk M, Polska B, Kunicki D, Kocik M, Grzęda K, Markiewicz W, Yilmaz O, Grabowski T.   +8 more
europepmc   +1 more source

Trends in Dermatopolymyositis Mortality, 1999–2022: A Nationwide Population‐Based Study, United States

Arthritis Care &Research, EarlyView.
We report the national burden of dermatopolymyositis mortality over the past quarter century using the US national vital statistics data. Age‐standardized mortality rates for dermatopolymyositis decreased at an annual rate of 3.8% each year, which was higher than the annual percent decrease for deaths from all other causes.
Elizabeth Matz, Ram R. Singh
wiley   +1 more source

Heparan sulphate binding controls in vivo half-life of the HpARI protein family. [PDF]

Elife
Colomb F, Jamwal A, Ogunkanbi A, Frangova T, Savage AR, Kelly S, Wright GJ, Higgins MK, McSorley HJ.   +8 more
europepmc   +1 more source