Results 121 to 130 of about 6,725,901 (296)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Oscillation of second-order half-linear difference equations

Applied Mathematics Letters, 2000
The authors obtain some new oscillation criteria for a second-order half-linear difference equation. The techniques based on Riccati type difference inequality are developed and examples, which illustrate the applications of the results, are also included.
Thandapani, E., Ravi, K.
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Double-distribution-function discrete Boltzmann model for combustion

, 2015
A 2-dimensional discrete Boltzmann model for combustion is presented. Mathematically, the model is composed of two coupled discrete Boltzmann equations for two species and a phenomenological equation for chemical reaction process.
Li, Yingjun, Lin, Chuandong, Xu, Aiguo, Zhang, Guangcai   +3 more
core   +1 more source

Oscillation criteria for second-order half-linear differential equations

Mathematical and Computer Modelling, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Half-linear regularization for nonconvex image restoration models

Inverse Problems & Imaging, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Coll, Bartomeu, Duran, Joan, Sbert, Catalina   +2 more
openaire   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Oscillation of a second order half-linear difference equation and the discrete Hardy inequality

, 2017
In local terms on finite and infinite intervals we obtain necessary and sufficient conditions for the conjugacy and disconjugacy of the following second order half-linear difference equation ∆(ρi|∆yi|∆yi) + vi|yi+1|yi+1 = 0, i = 0, 1, 2, . . . , where 1 <
A. Kalybay, D. Karatayeva, R. Oinarov, A. Temirkhanova   +3 more
semanticscholar   +1 more source

Oscillation results for second-order half-linear differential equations

Mathematical and Computer Modelling, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source