Results 81 to 90 of about 468,265 (345)

Structure formation from non-Gaussian initial conditions: multivariate biasing, statistics, and comparison with N-body simulations [PDF]

open access: yes, 2010
We study structure formation in the presence of primordial non-Gaussianity of the local type with parameters f_NL and g_NL. We show that the distribution of dark-matter halos is naturally described by a multivariate bias scheme where the halo overdensity
Cristiano Porciani   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Halo nevus [PDF]

open access: yesMedicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"
Halo nevi (leukoderma acquisitum centrifugum, Sutton's nevus, leukopigmentary nevus, perinevoid vitiligo or perinevoid leukoderma) are melanocytic nevi surrounded by a halo of hypopigmentation or depigmentation.
Jandrić-Kočić Marijana C.   +1 more
doaj   +1 more source

Determination of Dark Matter Halo Mass from Dynamics of Satellite Galaxies

open access: yes, 2017
We show that the mass of a dark matter halo can be inferred from the dynamical status of its satellite galaxies. Using 9 dark-matter simulations of halos like the Milky Way (MW), we find that the present-day substructures in each halo follow a ...
Jing, Y. P.   +4 more
core   +1 more source

Dynamical substructures of local metal-poor halo [PDF]

open access: green, 2023
Dashuang Ye   +3 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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