Results 81 to 90 of about 104,229 (292)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Cardiorespiratory fitness is associated with physical literacy in a large sample of Canadian children aged 8 to 12 years

BMC Public Health, 2018
Background The associations between cardiorespiratory fitness (CRF) and physical literacy in children are largely unknown. The aim of this study was to assess the relationships between CRF, measured using the 20-m shuttle run test (20mSRT), and ...
Justin J. Lang, Jean-Philippe Chaput, Patricia E. Longmuir, Joel D. Barnes, Kevin Belanger, Grant R. Tomkinson, Kristal D. Anderson, Brenda Bruner, Jennifer L. Copeland, Melanie J. Gregg, Nathan Hall, Angela M. Kolen, Kirstin N. Lane, Barbi Law, Dany J. MacDonald, Luc J. Martin, Travis J. Saunders, Dwayne Sheehan, Michelle R. Stone, Sarah J. Woodruff, Mark S. Tremblay   +20 more
doaj   +1 more source

A Lunar Halo [PDF]

Nature, 1914
A REMARKABLE coloured halo forming a complete circle about the moon was witnessed by me on Wednesday evening, December 2, at 7.15, my position being in North Shields. I am seventy-nine years of age, and never saw anything similar—that is, encircling the moon. It only lasted about seven or eight minutes. I am wondering if anyone else took much notice of
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Mengungkap Pencapaian Manusia dalam Karya Seni Pertunjukan "Rhythm 0" Melalui Ilustrasi Berjudul “Adornment”

Nirmana
Karya seni performa "Rhythm 0" oleh Marina Abramovic telah menjadi salah satu karya seni kontemporer yang paling kontroversial sepanjang sejarah seni. Meskipun karya ini menunjukkan aspek-aspek manusia yang universal, karya tersebut juga menghadirkan isu
Thomas Hanandry Dewanto
doaj   +1 more source

Determining the Scale Length and Height of the Milky Way’s Thick Disc Using RR Lyrae

Universe
Using the RR Lyrae surveys Gaia DR3 Specific Objects Study, PanSTARRS1 and ASAS-SN-II, we determine the Milky Way’s thick disc scale length and scale height as well as the radial scale length of the galaxy’s inner halo.
Roman Tkachenko, Katherine Vieira, Artem Lutsenko, Vladimir Korchagin, Giovanni Carraro   +4 more
doaj   +1 more source

An Extraordinary Lunar Halo [PDF]

, 1882
J. P. BARKAS
openalex   +1 more source

The halo sign [PDF]

Jornal Brasileiro de Pneumologia, 2017
Zanetti ,c, Gláucia, Hochhegger , , Bruno, Marchiori ,d, Edson, Marchiori ,d, Edson   +3 more
openaire   +5 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source