Results 81 to 90 of about 11,578 (241)
Deploying Microbial Synthesis for Halogenating and Diversifying Medicinal Alkaloid Scaffolds
Frontiers in Bioengineering and Biotechnology, 2020 Plants produce some of the most potent therapeutics and have been used for thousands of years to treat human diseases. Today, many medicinal natural products are still extracted from source plants at scale as their complexity precludes total synthesis ...
Samuel A. Bradley +2 more
doaj +1 more source
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Parabens, including butylparaben (BP), are widely used as antimicrobial preservatives in food, cosmetics, and pharmaceuticals, yet are poorly removed by conventional water treatment processes and pose potential risks to aquatic life and human health.
Lorena Maihury Santos Tsubouchi +8 more
wiley +1 more source
Halogenation of aromatic compounds: thermodynamic, mechanistic and ecological aspects
, 1998 Biological halogenation of aromatic compounds implies the generation of reducing equivalents in the form of e.g. NADH. Thermodynamic calculations show that coupling the halogenation step to a step in which the reducing equivalents are oxidized with a ...
Dolfing, J., Dolfing J
core +1 more source
A Solvent‐Free Synthesis of Imidazo[1,5‐a]pyridines Using CCl4 as an Oxidant
Journal of Heterocyclic Chemistry, EarlyView.A solvent‐free synthesis of imidazo[1,5‐a]pyridines (Impys) using CCl4 as an oxidant reagent and DBU as the base is informed. An array of Impys derived from different benzylic, heteroaryl aldehydes and others was synthesized in moderate to good yields.
Alejandro Castillo‐Baltazar +5 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma +3 more
wiley +1 more source
Disinfection by-products from halogenation of aqueous solutions of terpenoids [PDF]
, 2010 We report the formation of trihalomethanes and other disinfection by-products from four polyfunctional terpenoids during simulated chlorination of natural waters.
Heitz, Anna +2 more
core +1 more source
ChemistryOpen, 2020 Screening for an interesting biocatalyst and its subsequent kinetic characterization depends on a reliable activity assay. In this work, a fluorometric assay based on the halogenation of 4‐methyl‐7‐diethylamino‐coumarin was established to monitor ...
Alexander V. Fejzagić +5 more
doaj +1 more source
Acta Crystallographica Section D, EarlyView.A structure of the flavin‐dependent single‐component tryptophan halogenase AetF bound to the non‐native tricyclic substrate tryptoline reveals a binding pose analogous to l‐tryptophan that directs C6‐first halogenation. Product analysis identifies 6,8‐dibromotryptoline as the final product.Flavin‐dependent halogenases (FDHs) offer a biocatalytic route ...
Simon Bork +3 more
wiley +1 more source
Benign by design: A paradigm shift in cosmetic ingredient development
International Journal of Cosmetic Science, EarlyView.Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota +3 more
wiley +1 more source
Enzymatic Halogenation of Tryptophan on a Gram Scale
, 2015 Frese M, Sewald N. Enzymatic Halogenation of Tryptophan on a Gram Scale. Angewandte Chemie International Edition. 2015;54(1):298-301.Halogenated arenes are important building blocks in medicinal and agrochemistry.
Frese, Marcel ; https://orcid.org/ +3 more
core +1 more source