Results 11 to 20 of about 1,936 (237)

Targeting and Readout Strategies for Fast Optical Neural Control In Vitro and In Vivo [PDF]

Journal of Neuroscience, 2007
Major obstacles faced by neuroscientists in attempting to unravel the complexity of brain function include both the heterogeneity of brain tissue (with a multitude of cell types present in vivo) and the high speed of brain information processing (with ...
Deisseroth, Karl, Gradinaru, Viviana, Kay, Kenneth, Mogri, Murtaza, Schneider, M. Bret, Thompson, Kimberly R., Zhang, Feng   +6 more
core   +2 more sources

Molecular details of the unique mechanism of chloride transport by acyanobacterial rhodopsin [PDF]

Physical Chemistry, Chemical Physics - PCCP, 2017
Microbial rhodopsins are well known as versatile and ubiquitous light-driven ion transporters and photosensors. While the proton transport mechanism has been studied in great detail, much less is known about various modes of anion transport.
Bondar, Ana-Nicoleta, Brown, Leonid S., Harris, Andrew, Heberle, Joachim, Hughes-Visentin, Alexandra, Maia, Raiza, Pranga-Sellnau, Franziska, Resler, Tom, Saita, Mattia   +8 more
core   +2 more sources

Cyanorhodopsin-II represents a yellow-absorbing proton-pumping rhodopsin clade within cyanobacteria. [PDF]

ISME J
Microbial rhodopsins are prevalent in many cyanobacterial groups as a light-energy-harvesting system in addition to the photosynthetic system. It has been suggested that this dual system allows efficient capture of sunlight energy using complementary ...
Hasegawa-Takano M, Hosaka T, Kojima K, Nishimura Y, Kurihara M, Nakajima Y, Ishizuka-Katsura Y, Kimura-Someya T, Shirouzu M, Sudo Y, Yoshizawa S.   +10 more
europepmc   +4 more sources

Characterization of the Proton-Transporting Photocycle of Pharaonis Halorhodopsin [PDF]

, 2000
The photocycle of pharaonis halorhodopsin was investigated in the presence of 100mM NaN3 and 1M Na2SO4. Recent observations established that the replacement of the chloride ion with azide transforms the photocycle from a chloride-transporting one into a ...
Ágnes Kulcsár, Géza I. Groma, Janos Κ. Lanyi, György Váró   +3 more
openalex   +3 more sources

Genomic Insights into Bacterioruberin and Halorhodopsin Biosynthetic Genes in 12 Halophilic Archaea Isolated from Korean Solar Salterns. [PDF]

J Microbiol Biotechnol
Halophilic archaea are extremophilic microorganisms uniquely adapted to thrive in hypersaline environments such as solar salterns, saline lakes, and brines.
Lee D, Hwang CY, Cho ES, You YH, Seo MJ.
europepmc   +2 more sources

Optogenetic regulation of chloride ions in reactive astrocytes may mitigate Parkinson's disease pathology. [PDF]

Sci Rep
Recent investigations underscore the pivotal role of reactive astrocytes in the pathogenesis of Parkinson’s disease (PD). As PD advances, reactive astrocytes lose their ability to degrade α-Synuclein (α-Syn) aggregates while concurrently increasing r ...
Lee EJ, Yoon HH, Jeon SR.
europepmc   +2 more sources

Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead. [PDF]

Adv Genet (Hoboken)
Optogenetics provides up to millisecond scale, cell type‐specific control of biology using light‐sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins and photoactivated enzymes to allosteric switches, surveys broad applications in neuroscience, molecular and cell biology, cardiology, immunology, and ...
Duan X, Zhu M, Gao S.
europepmc   +2 more sources

Optogenetics: Background, Methodological Advances and Potential Applications for Cardiovascular Research and Medicine [PDF]

, 2020
Optogenetics is an elegant approach of precisely controlling and monitoring the biological functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution by using optical system and genetic engineering technologies. The
Joshi, Jyotsna, Rubart, Michael, Zhu, Wuqiang   +2 more
core   +1 more source

The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants

Journal of Biological Chemistry, 2020
Microbial rhodopsins are versatile and ubiquitous retinal-binding proteins that function as light-driven ion pumps, light-gated ion channels, and photosensors, with potential utility as optogenetic tools for altering membrane potential in target cells ...
J. Besaw, Wei-lin Ou, T. Morizumi, B. Eger, J. D. Sanchez Vasquez, Jessica Chu, Andrew L. Harris, L. Brown, R. Miller, O. Ernst   +9 more
semanticscholar   +1 more source

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources