Results 21 to 30 of about 1,936 (237)
Optogenetics: Molecular and Optical Tools for Controlling Life with Light [PDF]
, 2013 Optogenetic tools are genetically-encoded reagents that, when targeted to specific brain cells, enable their activity to be controlled by light. These tools are having broad impact on science, and may serve clinical roles as well.
Aravanis +31 more
core +1 more source
A roadmap to integrate astrocytes into Systems Neuroscience. [PDF]
, 2020 Systems neuroscience is still mainly a neuronal field, despite the plethora of evidence supporting the fact that astrocytes modulate local neural circuits, networks, and complex behaviors. In this article, we sought to identify which types of studies are
De Pittà, Maurizio +7 more
core +2 more sources
Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins. [PDF]
Adv Sci (Weinh)As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Duan X +14 more
europepmc +2 more sources
Carbon fixation and rhodopsin systems in microbial mats from hypersaline lakes Brava and Tebenquiche, Salar de Atacama, Chile [PDF]
, 2021 In this work, molecular diversity of two hypersaline microbial mats was compared by Whole Genome Shotgun (WGS) sequencing of environmental DNA from the mats.
Contreras, Emanuel +4 more
core +1 more source
Frontiers in Microbiology, 2014 We analyzed the prokaryotic community structure of a saltern pond with 21 % total salts located in Isla Cristina, Huelva, Southwest Spain, close to the Atlantic ocean coast.
Ana Beatriz eFernández +6 more
doaj +1 more source
Journal of Biological Chemistry, 1990 We cloned and sequenced the gene coding for the polypeptide of a halorhodopsin in Natronobacterium pharaonis (named here pharaonis halorhodopsin). Peptide sequencing of cyanogen bromide fragments, and immunoreactions of the protein and synthetic peptides
J. Lanyi +4 more
semanticscholar +1 more source
Tools, methods, and applications for optophysiology in neuroscience
Frontiers in Molecular Neuroscience, 2013 The advent of optogenetics and genetically-encoded photosensors has provided neuroscience researchers with a wealth of new tools and methods for examining and manipulating neuronal function in vivo.
Niklas eSmedemark-Margulies +1 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2016 Presently there exists no cure for spinal cord injury. However, transplantation of embryonic tissue into spinal cord lesions resulted in axon outgrowth across the lesion site and some functional recovery, fostering hope for future stem cell therapies ...
Anne Tscherter +3 more
doaj +1 more source
Mediators of Inflammation, 2016 Chronic pain originating from neuronal damage remains an incurable symptom debilitating patients. Proposed molecular modalities in neuropathic pain include ion channel expressions, immune reactions, and inflammatory substrate diffusions.
Gum Hwa Lee, Sang Seong Kim
doaj +1 more source
Iso-halorhodopsin: a stable, 9-cis retinal containing photoproduct of halorhodopsin
Biophysical Journal, 1987 Dark-adapted halorhodopsin is a mixture of 13-cis and all-trans retinal chromophoric species. It is known that illumination with blue light increases the all-trans content, and this is reversed partially by brief red illumination. We now find that extended red-light illumination produces a third spectroscopic form.
Zimányi, L., Lanyi, J.K.
openaire +2 more sources