Results 51 to 60 of about 1,936 (237)

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

Microbial rhodopsins on leaf surfaces of terrestrial plants [PDF]

, 2011
Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Environmental Microbiology 14 (2012):
Atamna-Ismaeel, Nof, Beja, Oded, Belkin, Shimshon, Finkel, Omri M., Glaser, Fabian, Iluz, David, Post, Anton F., Schneider, Ron, Sharon, Itai, Spudich, John L., von Mering, Christian, Vorholt, Julia A.   +11 more
core   +1 more source

Direct detection of the chloride release and uptake reactions of Natronomonas pharaonis halorhodopsin. [PDF]

J Biol Chem
Hamada C, Murabe K, Tsukamoto T, Kikukawa T.   +3 more
europepmc   +2 more sources

Light-driven proton or chloride pumping by halorhodopsin. [PDF]

Proceedings of the National Academy of Sciences, 1993
Halorhodopsin from Halobacterium halobium was purified and reconstituted with lipids from purple membranes. The resulting protein-containing membrane sheets were adsorbed to a planar lipid membrane and photoelectric properties were analyzed. Depending on light conditions, halorhodopsin acted either as a light-driven chloride pump or as a proton pump ...
Bamberg, E., Tittor, J., Oesterhelt, D.
openaire   +3 more sources

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, Volume 46, Issue 2, Page 445-474, March 2026.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Evolution of optogenetic microdevices

, 2015
Implementation of optogenetic techniques is a recent addition to the neuroscientists\u27 preclinical research arsenal, helping to expose the intricate connectivity of the brain and allowing for on-demand direct modulation of specific neural pathways ...
Berk, Michael, Kale, Rajas P., Kouzani, Abbas Z., Tye, Susannah J., Walder, Ken   +4 more
core   +1 more source

Natronomonas salsuginis sp. nov., a New Inhabitant of a Marine Solar Saltern [PDF]

, 2020
A halophilic archaeon, strain F20-122T, was isolated from a marine saltern of Isla Bacuta (Huelva, Spain). Cells were Gram-stain-negative, aerobic, and coccoid in morphology. It grew at 25-50 °C (optimum 37 °C), pH 6.5-9.0 (optimum pH 8.0), and 10-30% (w/
Durán Viseras, Ana, Sánchez-Porro Álvarez, Cristina, Ventosa Ucero, Antonio   +2 more
core   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Optoelectronic Interfaces for Nongenetic Modulation of Excitable Tissues

Small Methods, Volume 10, Issue 3, 9 February 2026.
This review summarizes recent advances in nongenetic optoelectronic technologies for the modulation of excitable biotissues, covering material selection, device design, and working principles, as well as characterization methods. Representative applications in in vitro and in vivo models of the cardiac, central, and peripheral nervous systems are ...
Qi Wang, Jinghua Li
wiley   +1 more source