Results 61 to 70 of about 1,936 (237)
, 2021 The last two decades have witnessed the emergence of optogenetics; a field that has given researchers the ability to use light to control biological processes at high spatio‐temporal and quantitative resolution, in a reversible manner with minimal side ...
Christie, John M., Zurbriggen, Matias D.
core +1 more source
Analogies between halorhodopsin and bacteriorhodopsin
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2000 The light-activated proton-pumping bacteriorhodopsin and chloride ion-pumping halorhodopsin are compared. They belong to the family of retinal proteins, with 25% amino acid sequence homology. Both proteins have seven alpha helices across the membrane, surrounding the retinal binding pocket. Photoexcitation of all-trans retinal leads to ion transporting
openaire +2 more sources
Addiction Biology, Volume 31, Issue 1, January 2026.ABSTRACT The insular cortex (IC) is known to underlie drug seeking and relapse for multiple drug classes, yet the precise role the IC plays in opioid use disorder (OUD) remains unclear. In preclinical models of OUD, inhibition of the IC has produced conflicting results, such that in some cases the IC seems to promote opioid seeking whereas in others ...
Rachel E. Clarke +8 more
wiley +1 more source
From Mutation to Mechanism: an Approach to Understand Photoreceptors Function [PDF]
Microbial rhodopsins and phytochromes are photoreceptors that use light to trigger biochemical processes. Upon light activation, they undergo a cyclic cascade of reactions leading to substrate transfer and/or conformational changes associated with the ...
La Greca, Mariafrancesca
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Writing the Engram: Epigenetic Mechanisms of Memory Allocation
Journal of Neurochemistry, Volume 169, Issue 12, December 2025.Memory allocation refers to the selective recruitment of neurons to engram cells upon memory formation. While previous studies have documented the importance of intrinsic excitability and the transcription factor CREB on memory allocation, epigenetic mechanisms have remained poorly understood. Here, we summarise recent discoveries epigenetic mechanisms
Isabella Tarulli +3 more
wiley +1 more source
Crystal structure of Halobacterium salinarum halorhodopsin with a partially depopulated primary chloride-binding site [PDF]
, 2016 The transmembrane pump halorhodopsin in halophilic archaea translocates chloride ions from the extracellular to the cytoplasmic side upon illumination.
Heberle, Joachim +3 more
core +1 more source
Resonance Raman study of intermediates of the halorhodopsin photocycle [PDF]
FEBS Letters, 1987 The resonance Raman (RR) study of the retinal protein halorhodopsin (HR578) was extended to two of its photoproducts: HR and HRL 410 RR spectra of both species were recorded in H2O and D2O and compared with the RR spectra of the intermediates L550 and M412 from the bacteriorhodopsin photocycle.
Diller, R. +3 more
openaire +2 more sources
The genome of the square archaeon Haloquadratum walsbyi : life at the limits of water activity [PDF]
, 2006 BACKGROUND: The square halophilic archaeon Haloquadratum walsbyi dominates NaCl-saturated and MgCl(2 )enriched aquatic ecosystems, which imposes a serious desiccation stress, caused by the extremely low water activity.
Bolhuis, Henk +7 more
core +2 more sources
Neuroscience, 2016 The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors.
Ada C. Felix-Ortiz +5 more
semanticscholar +1 more source
Optogenetic Inhibition of the Orbitofrontal Cortex Disrupts Inhibitory Control during Stop-Change Performance in Male Rats. [PDF]
eNeuroHistorically, the orbitofrontal cortex (OFC) has been implicated in a variety of behaviors ranging from reversal learning and inhibitory control to more complex representations of reward value and task space.
Brockett AT +3 more
europepmc +2 more sources