Development of Optogenetic Tools for Manipulating Neuronal Activity and Behaviour in Zebrafish [PDF]
, 2016 Integration of sensory input and computation of behavioural output is a dynamic process involving diverse populations of cells often distributed throughout the brain. To study this topic, monitoring neuronal activity from a large population of cells and
Esteves, Rita Maria Santos
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Photogenetic Retinal Prosthesis
, 2010 The last few decades have witnessed an immense effort to develop working retinal implants for patients suffering from retinal degeneration diseases such as retinitis pigmentosa.
Grossman, Nir, Grossman, Nir
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Chromophore/protein and chromophore/anion interactions in halorhodopsin
Biophysical Journal, 1988 Halorhodopsin (HR), the light-driven chloride transport pigment of Halobacterium halobium, was bleached and reconstituted with retinal analogues with the pi electron system interrupted at different locations (dihydroretinals). The absorption maxima of the artificial pigments formed with the dihydroretinals are found to be very similar to those of the ...
Lanyi, J.K. +5 more
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Assessment of GABAA mediated changes in excitability in mouse somatosensory neurons [PDF]
GABA and glycine are the two main inhibitory neurotransmitters in the central nervous system mediating fast inhibitory transmission. In general, inhibitory neurotransmitters are expected to be analgesic owing to their hyperpolarising and shunting actions
Sohns, Kyra Kim
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Sensory information processing in mouse barrel cortex [PDF]
, 2019 Processazione dell'informazione sensoriale nella "barrel cortex" di ...
Varani, Stefano
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Dentate gyrus is needed for memory retrieval
Molecular PsychiatryThe hippocampus is crucial for acquiring and retrieving episodic and contextual memories. In previous studies, the inactivation of dentate gyrus (DG) neurons by chemogenetic- and optogenetic-mediated hyperpolarization led to opposing conclusions about DG’
Alejandro Carretero-Guillén +10 more
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Amygdala Inputs to the Ventral Hippocampus Bidirectionally Modulate Social Behavior
Journal of Neuroscience, 2014 Impairments in social interaction represent a core symptom of a number of psychiatric disease states, including autism, schizophrenia, depression, and anxiety.
Ada C. Felix-Ortiz, K. Tye
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Feasibility of using adjunctive optogenetic technologies in cardiomyocyte phenotyping – from the single cell to the whole heart [PDF]
, 2019 In 1791 Galvani established that electricity activated excitable cells. In the two centuries that followed, electrode stimulation of neuronal, skeletal and cardiac muscle became the adjunctive method of choice in experimental, electrophysiological, and ...
Bub, G, Daniels, Matthew
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Bioinspired light-driven chloride pump with helical porphyrin channels
Nature CommunicationsArtificial ion channels have potential in a range of applications, but achieving performance comparable to biological channels has been challenging. Here, the authors report an artificial, light-driven chloride pump, inspired by halorhodopsin, with a ...
Chao Li +6 more
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Basal forebrain projections to the lateral habenula modulate aggression reward
Nature, 2016 Maladaptive aggressive behaviour is associated with a number of neuropsychiatric disorders and is thought to result partly from the inappropriate activation of brain reward systems in response to aggressive or violent social stimuli.
S. Golden +19 more
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