Results 181 to 190 of about 95,708 (262)

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Effects of Hydrodynamic Ozonated Water Processing on the Thermal Stability and Structural Integrity of the Human Amniotic Membrane. [PDF]

J Funct Biomater
Belfort MGS, Santos FDRP, Carvalho MCO, Santos ACD, Marrafa PALI, Neto JGO, Lima CJ, Fernandes AB.   +7 more
europepmc   +1 more source

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Host genetic determinants of HTLV-1 infection outcomes. [PDF]

Immunol Res
Akbarin MM, Farjami Z, Álvarez HR.
europepmc   +1 more source

Leveraging Crisis Management for Minimising Brand Cancellation

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Brand misconduct can trigger negative consumer responses and escalate into brand crises. Effective crisis management is therefore essential to mitigate such responses and enhance organisational resilience. This study investigates the impact of various crisis communication strategies on consumer engagement and subsequent brand cancellation ...
Liyun Liu, Catherine Prentice, Susan Zeidan   +2 more
wiley   +1 more source

Functional electrical stimulation for major depressive disorder: Protocol for a pilot randomized controlled trial. [PDF]

PLoS One
Gholamali Nezhad F, Yu H, Demchenko I, Iwasa SN, DiNunzio S, Ghosh R, Zariffa J, Masani K, Lou W, Mulsant BH, Naguib HE, Popovic MR, Bhat V.   +12 more
europepmc   +1 more source

The Effect of CEO Narcissism on the Quality of Environmental, Social, and Governance Reporting—Evidence From Listed German Companies

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study explores how CEO narcissism—a salient individual trait within the upper echelons of corporate leadership—shapes the quality of environmental, social, and governance (ESG) reporting in large German firms. Drawing on data from 109 DAX, MDAX, and SDAX companies between 2017 and 2021 (545 firm‐year observations), we find that ...
Jennifer Zeppenfeld, Finja Lena Kind, Rainer Lueg   +2 more
wiley   +1 more source

Amniotic Membrane-Derived Factors in Immunomodulation and Regenerative Medicine: Current Evidence and Emerging Perspectives in Biomaterials and 3D Bioprinting. [PDF]

J Funct Biomater
Obradović H, Gazikalović I, Okić Đorđević I, Momčilović S, Aleksandrović D, Jeftić N, Jauković A.   +6 more
europepmc   +1 more source