Results 121 to 130 of about 845,146 (320)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

open access: yesAdvanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin   +12 more
wiley   +1 more source

Biocatalytic Regioselective C‐Formylation of Resorcinol Derivatives

open access: yesAngewandte Chemie, EarlyView.
An acyltransferase from Chromobacterium sphagni (CsATase) was identified that catalyzes the regioselective formylation of resorcinol substrates. The formylation of substituted resorcinol derivatives yielded mono‐formylated products with up to 99% conversion and up to 74% isolated yield.
Lilla Gal   +6 more
wiley   +2 more sources

Influence of Hydrogen‐Incorporation on the Bulk Electronic Structure and Chemical Bonding in Palladium

open access: yesAdvanced Science, EarlyView.
Hydrogen incorporation in palladium is directly probed using in situ ambient‐pressure hard X‐ray photoelectron spectroscopy under realistic, application‐relevant conditions. Correlated structural, spectroscopic, and theoretical analysis reveals how hydrogen loading modifies structure, electronic structure, and metal‐hydrogen bonding, resolving long ...
Lars J. Bannenberg   +8 more
wiley   +1 more source

Multiple interactions and AGK rules in pQCD

open access: yes, 2007
We review some aspects of multiple interactions in High Energy QCD; we discuss in particular AGK rules and present some results concerning multiple interactions in the context of jet production.Comment: Talk given by MS at 12th International Conference ...
Bartels, J., Salvadore, M., Vacca, G. P.
core  

Precise Tailoring of Charge Transport Characteristics in Zr and Hf Doped Indium Tin Oxide Thin Film Transistors

open access: yesAdvanced Electronic Materials, EarlyView.
Zirconium, hafnium, and mixed zirconium/hafnium doped indium tin oxide thin films are accessible by atomic layer deposition. The amorphous functional films are about 8 nm thick and show a high interdiffusion of all elements. Their transistor characteristics can be modulated depending on the amount of Zr and Hf oxide phases incorporated in these thin ...
Marie Isabelle Büschges   +5 more
wiley   +1 more source

Multi‐Crystal X‐Ray Diffraction (MCXRD) Bridges the Crystallographic Characterisation Gap in Chemistry and Materials Science: Application to MOFs

open access: yesAngewandte Chemie, EarlyView.
Multi‐crystal X‐ray diffraction (MCXRD) methods allow accurate structural characterisation with crystals too small for single‐crystal X‐ray diffraction and too large for electron diffraction, as demonstrated here for metal‐organic frameworks, and alleviate the radiation‐induced chemical changes that can result from using high‐intensity X‐ray sources to
Joshua P. Smith   +9 more
wiley   +2 more sources

ESTONIAN NATIONAL ENERGY STRATEGY [PDF]

open access: yesOil Shale, 2022
Arvi Hamburg
doaj   +1 more source

A Large TPC Prototype with MPGD Readout: Status and Plans

open access: yes, 2009
The use of a TPC in future collider experiments needs significant research and development. Within the EUDET program an infrastructure has been designed and built to allow the efficient testing of TPC prototypes under realistic conditions.
Behnke, Ties   +3 more
core  

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