Results 151 to 160 of about 445,337 (327)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

open access: yesAdvanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi   +11 more
wiley   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

open access: yesAdvanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu   +13 more
wiley   +1 more source

Compatible Hamilton cycles in random graphs [PDF]

open access: green, 2014
Michael Krivelevich   +2 more
openalex   +1 more source

Synergistic Optimization Between Chromium Local Coordination States Toward Self‐Powered High‐Repeatability Near‐Infrared Mechanoluminescence

open access: yesAdvanced Science, EarlyView.
Herein, a Cr3+‐activated tunable near‐infrared (650–1000 nm) self‐powered mechanoluminescence material with high intensity and repeatability is innovatively developed. This work focuses on optimizing multiple Cr3+ local coordination environments (isolated Cr3+, Cr3+ pair, and Cr3+ cluster) to deeply understand the electron transfer mechanism behind the
Yao Xiao   +7 more
wiley   +1 more source

Hamilton cycles in highly connected and expanding graphs [PDF]

open access: green, 2006
Dan Hefetz   +2 more
openalex   +1 more source

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