Results 151 to 160 of about 3,567,425 (361)

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Unravel the Effects of UV Light on the Lattice Stability of Perovskite via Numerical Simulation

Advanced Science, EarlyView.
The perovskite lattice stability against UV light is enhanced via appropriate doping and additive strategies, which promotes their future applications in (near) space environments. Abstract The light degradation of perovskite greatly hinders the commercialization of perovskite solar cells, which is yet to be resolved, despite the many attempts.
Qihang Yang, Yuqin Liu, Xi Tao, Yanyan An, Lory Wenjuan Yang, Qin Liu, Ruqiang Dou, Na Liu, Fan Xu, Ryan Taoran Wang, Gu Xu   +10 more
wiley   +1 more source

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

Advanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao, Junbiao Zhang, Yanli Liu, Lili Wang, Chunxi Huang, Wei Chi, Meixia An   +6 more
wiley   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

Advanced Science, EarlyView.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun, Qili Qian, Luwen Xu, Bowen Gao, Ting Li, Yin Li, Jiayi Zheng, Qiaoyu Fu, Xi Cheng, Nuo Chen, Sijia Wang, Liang Zhang, Caiyue Liu, Qingfeng Li   +13 more
wiley   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

Advanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam, Stephanie Watson, Yogambha Ramaswamy, Gurvinder Singh   +3 more
wiley   +1 more source

Optimizing Surface *H Coverage over Cu2O/Co3O4 Heterojunction Enables Efficient Neutral Electrocatalytic Hydrogenation of 5‐hydroxymethylfurfural to 2,5‐dihydroxymethylfuran

Advanced Science, EarlyView.
This work presents a heterojunction strategy, wherein Co3O4 functions as a redox‐active cocatalyst to stabilize Cu⁺ sites and finely tune the electronic structure of Cu2O. Such interfacial modulation accelerates H2O dissociation kinetics under neutral conditions and enables optimal surface *H coverage, thereby facilitating efficient HMF electro ...
Yun Ge, Wei Wang, Xiao‐Qiang Pan, Jia‐Wei Huang, Jie‐Jie Chen, Wu‐Jun Liu, Yuqin Zou, Han‐Qing Yu   +7 more
wiley   +1 more source

Resolving the Capacity‐Stability‐Cost Trilemma in Multi‐Principal‐Element Hydrogen Storage Alloys Through Multi‐Objective Optimization

Advanced Science, EarlyView.
This work presents a paradigm‐shifting multi‐objective optimization strategy for hydrogen storage materials, simultaneously addressing the intrinsic capacity‐stability‐cost trade‐off through precisely engineered Ti‐Zr‐Mn‐Cr‐VFe multi‐principal‐element alloys in C14 Laves phases.
Panpan Zhou, Qianwen Zhou, Wenzhe Liu, Nuo Lei, Yongpeng Chen, Jinghua Jiang, Dan Song, Hai‐Wen Li, Qin‐Yi Li, Lixin Chen, Xuezhang Xiao   +10 more
wiley   +1 more source

Engineering Oxygen‐Terminated Hexagonal MBene for Accelerated Lithium Migration and Exceptional Lithium‐Ion Battery Performance

Advanced Science, EarlyView.
The synthesis of ultrathin Ti‐based 2D hexagonal transition metal borides (TiBTx h‐MBene) via ZnCl2 molten salt and the formed disorderly low‐boiling‐point Zn‐In intermediate, followed by TBAOH delamination. The delaminated structure, with O‐ and Cl‐terminations, improves Li‐ion transport, achieving 530 mAh g−1 at 0.1 A g−1 and 120 mAh g−1 at 10 A g−1,
Qing Shen, LeYang Wang, Pengjie Jiang, Jinming Wang, Yaxin Di, Hui Mei, Junjie Wang, Laifei Cheng   +7 more
wiley   +1 more source

Regulating Spin Polarization through Topological Defects in Carbon‐Based Metal‐Free Catalyst for Enhanced Fenton‐Like Activity

Advanced Science, EarlyView.
A topological defect engineering strategy is proposed to regulate the spin polarization by introducing pentagon defects on the edge of carbon nanotubes. Theoretical and experimental results indicate that the incorporation of pentagon defects on the edge induces a spin polarization, and more spin‐down electrons locate below the Fermi level, which ...
Huajie Zhong, Zeyu Gong, Xi Chen, Bin Zhang, Tao Zhan, Jiaxing Yu, Yu Hou, Yuan Tao, Qi Fu, Huangsheng Yang, Jiating Zheng, Duochu Su, Ganggang Li, Junhui Wang, Gangfeng Ouyang   +14 more
wiley   +1 more source