Results 81 to 90 of about 178,127 (290)

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

open access: yesAdvanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang   +15 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

open access: yesAdvanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie   +12 more
wiley   +1 more source

MetalCenter‐Dependent Selectivity Divergence in MN4 Single‐Atom Catalysts for Aerobic HMF Oxidation

open access: yesAdvanced Science, EarlyView.
Two single‐atom catalysts with M‐N4 configurations (FeN4 and CoN4) were developed for selective HMF oxidation. FeN4 achieves 93.9% selectivity toward FFCA via superoxide anions (O2•−), while CoN4 preferentially produces FDCA through hydroxyl radicals (•OH). DFT calculations reveal that distinct adsorption energies and charge redistribution at the metal
Haoyu Wang   +6 more
wiley   +1 more source

Hamilton family collection

open access: yes
This collection contains documents, photographs, and memorabilia of the Hamilton, Kirkpatrick, and Montgomery families of Sumner County, Tennessee, and the Hamilton and Blakely families of Nevada County ...
Hamilton family
core  

Tailored Catalytic Microenvironments Enable Efficient Electrochemical Ammonia Production

open access: yesAdvanced Science, EarlyView.
This study shows that Co2+ substitution in inverse spinel FeFeCoO4 constructs an integrated catalytic microenvironment for efficient nitrate‐to‐ammonia reduction. Jahn–Teller distortion activates Fe sites for *H generation, while hard–soft acid–base regulated dual‐metal sites optimize proton‐coupled electron transfer and intermediate adsorption ...
Qi Zhang   +8 more
wiley   +1 more source

William P. Hamilton Sr. family papers

open access: yes
This collection contains papers and photographs from the William P. Hamilton Sr. family of Little Rock.
Hamilton, Don
core  

Ventilation defect burden predicts lung cancer resection outcomes

open access: yesERJ Open Research
Background Abnormal ventilation prior to lung cancer resection has not been investigated using modern ventilation imaging modalities and may better predict postoperative outcomes than guideline-recommended lung function tests.
Nisarg Radadia   +13 more
doaj   +1 more source

One‐Dimensional RuIrTe Nanotubes with Amorphous Surface as a Highly Active and Stable Electrocatalyst Toward Oxygen Evolution Reaction in Acidic Media

open access: yesAdvanced Science, EarlyView.
A rational etching‐induced reconstruction strategy is demonstrated to fabricate one‐dimensional RuIrTe ternary nanotubes with a unique amorphous‐crystalline heterostructure. This hierarchical architecture synergistically optimizes mass transport and electronic configurations, delivering record‐breaking performance in proton exchange membrane water ...
Zhi Liang Zhao   +4 more
wiley   +1 more source

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