Results 71 to 80 of about 2,972 (249)

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

open access: yesAdvanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio   +6 more
wiley   +1 more source

Isometric embeddings in Hamming graphs

open access: yesJournal of Combinatorial Theory, Series B, 1990
An \(O(n^ 3)\)-algorithm is established which embeds a given graph isometrically into a Hamming graph (i.e., a Cartesian product of complete graphs) whenever possible, and recognizes non-embeddable graphs. From the algorithm several characterizations of the embeddable graphs are derived.
openaire   +2 more sources

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan   +29 more
wiley   +1 more source

On a Conjecture Regarding Identification in Hamming Graphs

open access: yesThe Electronic Journal of Combinatorics, 2019
In 2013, Goddard and Wash studied identifying codes in the Hamming graphs $K_q^n$. They stated, for instance, that $\gamma^{ID}(K_q^n)\leqslant q^{n-1}$ for any $q$ and $n\geqslant 3$. Moreover, they conjectured that $\gamma^{ID}(K_q^3)=q^2$. In this article, we show that $\gamma^{ID}(K_q^3)\leqslant q^2-q/4$ when $q$ is a power of four, which ...
Ville Junnila   +2 more
openaire   +4 more sources

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

open access: yesAdvanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen   +8 more
wiley   +1 more source

Burning Hamming graphs

open access: yesGraphs and Combinatorics
The Hamming graph $H(n,q)$ is defined on the vertex set $[q]^n$ and two vertices are adjacent if and only if they differ in precisely one coordinate. Alon \cite{Alon} proved that the burning number of $H(n,2)$ is $\lceil\frac n2\rceil+1$. In this note we give a short proof of a fact that the burning number of $H(n,q)$ is $(1-\frac 1q)n+O(\sqrt{n\log n})
openaire   +3 more sources

On an isoperimetric problem for Hamming graphs

open access: yesDiscrete Applied Mathematics, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Completely Transitive Codes in Hamming Graphs

open access: yesEuropean Journal of Combinatorics, 1999
A code \(C\) in the graph \(\Gamma\) is a non-empty subset of the vertex set \(V\) of \(\Gamma\). Completely transitive codes are a special class of completely regular codes. A code in the graph \(\Gamma\) is called a completely transitive code if there exists a subgroup \(G\) of the group of automorphisms of \(\Gamma\), such that each cell \(C_i\) in ...
Michael Giudici, Cheryl E. Praeger
openaire   +2 more sources

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

open access: yesAdvanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi   +9 more
wiley   +1 more source

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