Results 1 to 10 of about 259,291 (341)

Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals [PDF]

eLife
Animals respond to environmental cues to time phenological events, but the intrinsic mechanism of circannual timing remains elusive. We used transcriptomic sequencing and frequent sampling of multiple hypothalamic nuclei in Djungarian hamsters to examine
Calum Stewart, T Adam Liddle, Elisabetta Tolla, Jo Edward Lewis, Christopher Marshall, Neil P Evans, Peter J Morgan, Fran JP Ebling, Tyler J Stevenson   +8 more
doaj   +2 more sources

Preclinical Models of Oropouche Virus Infection and Disease [PDF]

Pathogens
Oropouche virus (OROV) is an emerging and underreported arbovirus with dengue-like symptoms confounding diagnosis. OROV is also neuroinvasive, with a small number of cases presenting severe neurological symptoms.
Daniel Morley, Emma Kennedy, Stuart Dowall   +2 more
doaj   +2 more sources

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

Emerging Microbes and Infections, 2020
Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of deaths worldwide.
K. Rosenke, Kimberly Meade-White, M. Letko, Chad S. Clancy, Frederick Hansen, Yanan Liu, A. Okumura, Tsing-Lee Tang-Huau, Rong Li, G. Saturday, F. Feldmann, D. Scott, Zhongde Wang, V. Munster, M. Jarvis, H. Feldmann   +15 more
semanticscholar   +2 more sources

Global changes in gene expression related to Opisthorchis felineus liver fluke infection reveal temporal heterogeneity of a mammalian host response

Food and Waterborne Parasitology, 2022
The food-borne trematode Opisthorchis felineus colonizes bile ducts of the liver of fish-eating mammals including humans. Among chronically infected individuals, this opisthorchiasis involves hepatobiliary problems, including chronic inflammation ...
Maria Y. Pakharukova, Oxana Zaparina, Nina V. Baginskaya, Viatcheslav A. Mordvinov   +3 more
doaj   +1 more source

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

Science Translational Medicine, 2022
Transmission-blocking strategies that slow the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are needed.
S. Langel, Susan Johnson, Clarissa I. Martinez, Sarah N. Tedjakusuma, Nadine Peinovich, E. Dora, P. Kuehl, Hammad Irshad, E. Barrett, A. Werts, Sean N. Tucker   +10 more
semanticscholar   +1 more source

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model

Vaccines, 2021
The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging diseases.
Izabela K Ragan, Lindsay M Hartson, Taru S Dutt, Andres Obregon-Henao, Rachel M Maison, Paul Gordy, Amy Fox, Burton R Karger, Shaun T Cross, Marylee L Kapuscinski, Sarah K Cooper, Brendan K Podell, Mark D Stenglein, Richard A Bowen, Marcela Henao-Tamayo, Raymond P Goodrich   +15 more
doaj   +1 more source

Human Adenovirus and Influenza A Virus Exacerbate SARS-CoV-2 Infection in Animal Models

Microorganisms, 2023
In this study, we investigated the features of the infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro and in vivo. The determination of infectious activity of viruses and
Victor A. Svyatchenko, Vladimir A. Ternovoi, Roman Y. Lutkovskiy, Elena V. Protopopova, Andrei S. Gudymo, Nataliya V. Danilchenko, Ivan M. Susloparov, Nataliya P. Kolosova, Alexander B. Ryzhikov, Oleg S. Taranov, Vladimir V. Omigov, Elena V. Gavrilova, Alexander P. Agafonov, Rinat A. Maksyutov, Valery B. Loktev   +14 more
doaj   +1 more source

Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

eLife, 2022
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19).
Zaigham Abbas Rizvi, Rajdeep Dalal, Srikanth Sadhu, A. Binayke, Jyotsna Dandotiya, Yashwant Kumar, T. Shrivastava, S. Gupta, Suruchi Aggarwal, M. Tripathy, D. Rathore, A. Yadav, G. Medigeshi, A. Pandey, Sweety Samal, Shailendra Asthana, A. Awasthi   +16 more
semanticscholar   +1 more source

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

Journal of Lipid Research, 2023
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast, Nicole El-Darzi, Yong Li, Irina A. Pikuleva   +3 more
doaj   +1 more source

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

Frontiers in Immunology, 2021
Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation.
Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D’El-Rei Hermida, Jonathan L. M. Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P. Ramos, Gabriel R. Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri, Carlos Henrique Nery Costa, Washington L. C. dos-Santos   +11 more
doaj   +1 more source