Results 1 to 10 of about 306,860 (343)

Global changes in gene expression related to Opisthorchis felineus liver fluke infection reveal temporal heterogeneity of a mammalian host response

Food and Waterborne Parasitology, 2022
The food-borne trematode Opisthorchis felineus colonizes bile ducts of the liver of fish-eating mammals including humans. Among chronically infected individuals, this opisthorchiasis involves hepatobiliary problems, including chronic inflammation ...
Maria Y. Pakharukova, Oxana Zaparina, Nina V. Baginskaya, Viatcheslav A. Mordvinov   +3 more
doaj   +1 more source

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model

Vaccines, 2021
The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging diseases.
Izabela K Ragan, Lindsay M Hartson, Taru S Dutt, Andres Obregon-Henao, Rachel M Maison, Paul Gordy, Amy Fox, Burton R Karger, Shaun T Cross, Marylee L Kapuscinski, Sarah K Cooper, Brendan K Podell, Mark D Stenglein, Richard A Bowen, Marcela Henao-Tamayo, Raymond P Goodrich   +15 more
doaj   +1 more source

Human Adenovirus and Influenza A Virus Exacerbate SARS-CoV-2 Infection in Animal Models

Microorganisms, 2023
In this study, we investigated the features of the infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro and in vivo. The determination of infectious activity of viruses and
Victor A. Svyatchenko, Vladimir A. Ternovoi, Roman Y. Lutkovskiy, Elena V. Protopopova, Andrei S. Gudymo, Nataliya V. Danilchenko, Ivan M. Susloparov, Nataliya P. Kolosova, Alexander B. Ryzhikov, Oleg S. Taranov, Vladimir V. Omigov, Elena V. Gavrilova, Alexander P. Agafonov, Rinat A. Maksyutov, Valery B. Loktev   +14 more
doaj   +1 more source

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

Journal of Lipid Research, 2023
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast, Nicole El-Darzi, Yong Li, Irina A. Pikuleva   +3 more
doaj   +1 more source

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

Frontiers in Immunology, 2021
Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation.
Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D’El-Rei Hermida, Jonathan L. M. Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P. Ramos, Gabriel R. Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri, Carlos Henrique Nery Costa, Washington L. C. dos-Santos   +11 more
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Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia

Frontiers in Integrative Neuroscience, 2022
We tested the hypothesis that a temporary period of circadian arrhythmia would transiently impair recall of an aversive memory in Siberian hamsters (Phodopus sungorus).
Athreya Steiger, Julia Farfan, Nathan Fisher, H. Craig Heller, Fabian-Xosé Fernandez, Norman F. Ruby   +5 more
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Histopathologic Characterization of Experimental Peracute SARS-CoV-2 Infection in the Syrian Hamster

Veterinary Sciences, 2023
Coronavirus Infectious Disease 2019 (COVID-19) initiated a global pandemic that thus far has resulted in the death of over 6.5 million people internationally.
Chad S. Clancy, Kimberly Meade-White, Carl Shaia, Greg Saturday, Heinz Feldmann, Kyle Rosenke   +5 more
doaj   +1 more source

Suppression of Circadian Timing and Its Impact on the Hippocampus

Frontiers in Neuroscience, 2021
In this article, I describe the development of the disruptive phase shift (DPS) protocol and its utility for studying how circadian dysfunction impacts memory processing in the hippocampus.
Norman F. Ruby
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Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models

Frontiers in Microbiology, 2020
We explored an emerging technology to produce anti-Hantaan virus (HTNV) and anti-Puumala virus (PUUV) neutralizing antibodies for use as pre- or post-exposure prophylactics.
Casey C. Perley, Rebecca L. Brocato, Hua Wu, Christoph Bausch, Priya P. Karmali, Jerel B. Vega, Melanie V. Cohen, Brandon Somerville, Steven A. Kwilas, Lucia M. Principe, Joshua Shamblin, Padmanabh Chivukula, Eddie Sullivan, Jay W. Hooper   +13 more
doaj   +1 more source

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

eLife, 2022
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing vaccines that were designed to ...
David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse H Erasmus   +14 more
doaj   +1 more source