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The role of photoperiod and melatonin in the control of seasonal reproduction in mammals [PDF]

open access: yesRoczniki Naukowe Polskiego Towarzystwa Zootechnicznego, 2020
Melatonin secreted by pineal cells is a hormone whose biosynthesis is coordinated by neurons of the master clock located in the hypothalamic suprachiasmatic nuclei (SCN), characterized by the generation of a 24-hour rhythm.
Izabela Szpręgiel, Danuta Wronska
doaj   +1 more source

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

open access: yesFrontiers in Immunology, 2021
Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation.
Caroline Vilas Boas de Melo   +11 more
doaj   +1 more source

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

open access: yeseLife, 2022
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing vaccines that were designed to ...
David W Hawman   +14 more
doaj   +1 more source

Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19

open access: yesMicrobiology Spectrum, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 2019 (COVID-19). However, the long-term health consequences of COVID-19 are not fully understood. We aimed to determine the long-term lung
Chi-Ju Hsu   +9 more
doaj   +1 more source

Suppression of Circadian Timing and Its Impact on the Hippocampus

open access: yesFrontiers in Neuroscience, 2021
In this article, I describe the development of the disruptive phase shift (DPS) protocol and its utility for studying how circadian dysfunction impacts memory processing in the hippocampus.
Norman F. Ruby
doaj   +1 more source

Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro

open access: yesViruses, 2020
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity.
Todd G. Smith   +12 more
doaj   +1 more source

Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia

open access: yesFrontiers in Integrative Neuroscience, 2022
We tested the hypothesis that a temporary period of circadian arrhythmia would transiently impair recall of an aversive memory in Siberian hamsters (Phodopus sungorus).
Athreya Steiger   +5 more
doaj   +1 more source

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model

open access: yesVaccines, 2021
The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging diseases.
Izabela K Ragan   +15 more
doaj   +1 more source

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis

open access: yesBiology, 2021
Cholesterol homeostasis in the retina, a sensory organ in the back of the eye, has been studied in mice but not hamsters, despite the latter being more similar to humans than mice with respect to their whole-body cholesterol maintenance. The goal of this
Nicole El-Darzi   +6 more
doaj   +1 more source

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