Results 1 to 10 of about 254,239 (215)

MRI of Syrian hamsters reveals SARS-CoV-2 variant-specific neuroinflammation [PDF]

Microbiology Spectrum
SARS-CoV-2 infection causes neurological manifestations in 30%–40% of patients, with reinfection exacerbating sequelae risks. Elucidating neuroinvasion mechanisms requires optimized animal models overcoming limitations of existing systems.
Yisi Tang, Xiaohui Wei, Kai Gao, Bowen Guan, Jiangning Liu, Xudong Shi   +5 more
doaj   +2 more sources

Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals [PDF]

eLife
Animals respond to environmental cues to time phenological events, but the intrinsic mechanism of circannual timing remains elusive. We used transcriptomic sequencing and frequent sampling of multiple hypothalamic nuclei in Djungarian hamsters to examine
Calum Stewart, T Adam Liddle, Elisabetta Tolla, Jo Edward Lewis, Christopher Marshall, Neil P Evans, Peter J Morgan, Fran JP Ebling, Tyler J Stevenson   +8 more
doaj   +2 more sources

Global changes in gene expression related to Opisthorchis felineus liver fluke infection reveal temporal heterogeneity of a mammalian host response

Food and Waterborne Parasitology, 2022
The food-borne trematode Opisthorchis felineus colonizes bile ducts of the liver of fish-eating mammals including humans. Among chronically infected individuals, this opisthorchiasis involves hepatobiliary problems, including chronic inflammation ...
Maria Y. Pakharukova, Oxana Zaparina, Nina V. Baginskaya, Viatcheslav A. Mordvinov   +3 more
doaj   +1 more source

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model

Vaccines, 2021
The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging diseases.
Izabela K Ragan, Lindsay M Hartson, Taru S Dutt, Andres Obregon-Henao, Rachel M Maison, Paul Gordy, Amy Fox, Burton R Karger, Shaun T Cross, Marylee L Kapuscinski, Sarah K Cooper, Brendan K Podell, Mark D Stenglein, Richard A Bowen, Marcela Henao-Tamayo, Raymond P Goodrich   +15 more
doaj   +1 more source

Human Adenovirus and Influenza A Virus Exacerbate SARS-CoV-2 Infection in Animal Models

Microorganisms, 2023
In this study, we investigated the features of the infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro and in vivo. The determination of infectious activity of viruses and
Victor A. Svyatchenko, Vladimir A. Ternovoi, Roman Y. Lutkovskiy, Elena V. Protopopova, Andrei S. Gudymo, Nataliya V. Danilchenko, Ivan M. Susloparov, Nataliya P. Kolosova, Alexander B. Ryzhikov, Oleg S. Taranov, Vladimir V. Omigov, Elena V. Gavrilova, Alexander P. Agafonov, Rinat A. Maksyutov, Valery B. Loktev   +14 more
doaj   +1 more source

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

Journal of Lipid Research, 2023
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast, Nicole El-Darzi, Yong Li, Irina A. Pikuleva   +3 more
doaj   +1 more source

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

Frontiers in Immunology, 2021
Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation.
Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D’El-Rei Hermida, Jonathan L. M. Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P. Ramos, Gabriel R. Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri, Carlos Henrique Nery Costa, Washington L. C. dos-Santos   +11 more
doaj   +1 more source

Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia

Frontiers in Integrative Neuroscience, 2022
We tested the hypothesis that a temporary period of circadian arrhythmia would transiently impair recall of an aversive memory in Siberian hamsters (Phodopus sungorus).
Athreya Steiger, Julia Farfan, Nathan Fisher, H. Craig Heller, Fabian-Xosé Fernandez, Norman F. Ruby   +5 more
doaj   +1 more source

Histopathologic Characterization of Experimental Peracute SARS-CoV-2 Infection in the Syrian Hamster

Veterinary Sciences, 2023
Coronavirus Infectious Disease 2019 (COVID-19) initiated a global pandemic that thus far has resulted in the death of over 6.5 million people internationally.
Chad S. Clancy, Kimberly Meade-White, Carl Shaia, Greg Saturday, Heinz Feldmann, Kyle Rosenke   +5 more
doaj   +1 more source

Suppression of Circadian Timing and Its Impact on the Hippocampus

Frontiers in Neuroscience, 2021
In this article, I describe the development of the disruptive phase shift (DPS) protocol and its utility for studying how circadian dysfunction impacts memory processing in the hippocampus.
Norman F. Ruby
doaj   +1 more source