Results 131 to 140 of about 6,431 (218)

Improving the inhibitors targeting enterovirus 71 3C proteinase [PDF]

, 2015
手足口病（HFMD）的频繁爆发，给许多婴幼儿带来痛苦甚至导致死亡。目前，没有任何疫苗和抗病毒治疗可用于预防和治疗手足口病。肠道病毒71型（EV71）是引起手足口病的主要病原体，它能够侵入中枢神经系统引起严重的后遗症。3C蛋白酶是EV71病毒复制过程中的一个重要蛋白酶，在EV71的成熟过程和拮抗宿主细胞的先天性免疫反应中有着重要作用。因此，EV713C蛋白酶是一个很好的抗EV71药物靶点。 AG7088最先是针对人病毒3C蛋白酶进行设计的，已被证实可有效抑制EV71病毒活性 ...
吴彩明
core  

Hand, Foot, and Mouth Disease in China: critical community size and spatial vaccination strategies

Hand Foot and Mouth Disease (HFMD) constitutes a considerable burden for health care systems across China. Yet this burden displays important geographic heterogeneity that directly affects the local persistence and the dynamics of the disease, and thus ...
Chang, Zhaorui, Grenfell, Bryan T., Hsiao, Victor, Lai, Shengjie, Liao, Qiaohong, Liu, Fengfeng, Metcalf, C. Jessica E., Takahashi, Saki, Van Boeckel, Thomas P., Xing, Weijia, Yu, Hongjie, Yuan, Chen, Zheng, Yaming   +12 more
core   +1 more source

The Nucleocapsid Protein Of Newcastle Disease Virus As A Carrier For The Vp1 Polypeptides Of Enterovirus 71 [PDF]

, 2005
Human enterovirus 71 (EV71) is an important human enterovirus which belongs to the Enterovirus genus of the Picornaviridae family. Large outbreaks of EV71 have been associated with severe central nervous disease (CNS) manifestations including the hand,
Sivasamugham, Lalita Ambigal
core  

Economic Burden Of Hand, Foot And Mouth Disease (Hfmd) In China

Value in Health, 2014
Zheng, Y, Yang, J, Yu, H
openaire   +2 more sources

Development of novel miRNA-based vaccines and antivirals against Enterovirus 71 [PDF]

, 2016
The Hand, Foot and Mouth Disease (HFMD) is caused by Enterovirus 71 (EV-A71) and Coxsackie viruses. Common HFMD symptoms are high fever (≥ 39oC), rashes, and ulcers but complications due to virulent EV-A71 may arise leading to cardiopulmonary failure and
Poh, Chit Laa *, Yee, Isabel Pin Tsin *
core  

Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease [PDF]

, 2017
AbuBakar, Andreoni, Ang, Arita, Arita, Bendig, Bessaud, Bracho, Brown, Castro, Chan, Chang, Chang, Chang, Chang, Chang, Chea, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Chern, Chua, Chumakov, Chung, Chung, Crabol, Drake, Feng, Fenton, Ferson, Fitzgerald, Flett, Flewett, Foo, Fujii, Fujimoto, Fukata, Gantt, Griffiths, Hagiwara, Hanson, He, Hirata, Ho, Hogarth, Hu, Huang, Huang, Huang, Huang, Hughes, Hung, Ishimaru, Kao, Kar, Kataoka, Khong, Kiener, Kim, Komatsu, Kontsek, Ku, Lee, Lee, Lei, Lei, Lei, Li, Li, Li, Liao, Lin, Lin, Lin, Lin, Lin, Lin, Lindenbaum, Liou, Liu, Liu, Liu, Liu, Lo, Lu, Lum, Machain-Williams, McMinn, McMinn, McMinn, Meng, Mirand, Mizuta, Mogensen, Morrison, Nagata, Nagata, Nagy, Nishimura, Nishimura, Ong, Ong, Ooi, Ooi, Pallansch, Pathinayake, Peng, Pilipenko, Plevka, Plevka, Plevka, Pliaka, Pérez-Ruiz, Rabenau, Reid, Rong, Rotbart, Sazaly, Schmidt, Second, Shah, Shia, Shih, Shih, Shih, Shultz, Solomon, Sutton-Hayes, Takeuchi, Tan, Tan, Tang, Tee, Thompson, Tu, Tung, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yamayoshi, Yamayoshi, Yamayoshi, Yan, Yang, Yang, Ye, Ye, Yi, Yu, Zhang, Zhang, Zhang, Zhang, Zhu, Zhu, Zhu, Zhuang   +166 more
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Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations [PDF]

, 2015
Chenghong Dong, Erxia Yang, Haijing Shi, Hongling Zhao, Jielai Xia, Jing Pu, Jingjing Wang, Junzhi Wang, Kien Chai Ong, Kum Thong Wong, Lei Guo, Li Jiang, Lichun Wang, Ling Wang, Longding Liu, Min Feng, Perera David, Pingfang Cui, Qihan Li, Qunying Mao, Rongcheng Li, Ruixiong Na, Soon Hao Tan, Teng Huang, Wei Cui, Xuanyi Wang, Yan Liang, Yanchun Che, Ying Zhang, Yun Liao, Zhaojun Mo, Zhenglun Liang, Zhenxin Zhou, Zhongping Xie   +33 more
core   +1 more source

Impact of meteorological factors on the incidence of childhood hand, foot, and mouth disease (HFMD) analyzed by DLNMs-based time series approach. [PDF]

Infect Dis Poverty, 2018
Qi H, Chen Y, Xu D, Su H, Zhan L, Xu Z, Huang Y, He Q, Hu Y, Lynn H, Zhang Z.   +10 more
europepmc   +1 more source

Emergence of Recombinant Subclade D3/Y in Coxsackievirus A6 Strains in Hand-Foot-and-Mouth Disease (HFMD) Outbreak in India, 2022. [PDF]

Microorganisms
Tikute S, Deshmukh P, Chavan N, Shete A, Shinde P, Yadav P, Lavania M.   +6 more
europepmc   +1 more source

Time series analysis of reported cases of hand, foot, and mouth disease from 2010 to 2013 in Wuhan, China [PDF]

, 2015

core   +1 more source