Results 131 to 140 of about 29,474 (248)

The Recruitment and Retention of Individuals With Intellectual Disability in Randomized Controlled Trials: A Scoping Review

open access: yesBritish Journal of Learning Disabilities, EarlyView.
ABSTRACT Background People with intellectual disabilities face significant health disparities and often encounter barriers in accessing healthcare services. Although research supports the need for reasonable adjustments to improve healthcare access for this population, implementation in acute healthcare settings remains limited.
Owen Doody   +5 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos   +16 more
wiley   +1 more source

Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks

open access: yesClinical &Experimental Allergy, EarlyView.
In the phase 3 KONFIDENT trial of oral sebetralstat for on‐demand treatment of hereditary angioedema attacks, many attacks induced moderate‐to‐extreme anxiety. Sebetralstat reduced anxiety versus placebo; time to reductions agreed with trial endpoints, such as time to beginning of symptom relief.
Timothy Craig   +24 more
wiley   +1 more source

Clinical characteristics of fatal cases of hand, foot and mouth disease in children. [PDF]

open access: yesFront Pediatr
Zhang X   +7 more
europepmc   +1 more source

Relational Wellbeing Amongst Care‐Experienced Young People in Transition in the Context of Covid 19

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Care‐experienced young people typically negotiate the transition to adulthood at a younger age than their peers in the general population and with less reliable access to support. Concerns have been raised that Covid 19 exacerbated the challenges they faced and widened the ‘care‐gap’.
Emily R. Munro, Seana Friel, Amy Lynch
wiley   +1 more source

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