Results 41 to 50 of about 6,664 (259)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An Intelligent Heuristic Manta-Ray Foraging Optimization and Adaptive Extreme Learning Machine for Hand Gesture Image Recognition

Big Data Mining and Analytics, 2023
The development of hand gesture recognition systems has gained more attention in recent days, due to its support of modern human-computer interfaces. Moreover, sign language recognition is mainly developed for enabling communication between deaf and dumb
Seetharam Khetavath, Navalpur Chinnappan Sendhilkumar, Pandurangan Mukunthan, Selvaganesan Jana, Lakshmanan Malliga, Subburayalu Gopalakrishnan, Sankuru Ravi Chand, Yousef Farhaoui   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Face Authenticated Hand Gesture Based Human Computer Interaction for Desktops

Cybernetics and Information Technologies, 2020
Hand gesture detection and recognition is a cutting-edge technology that is getting progressively applicable in several applications, including the recent trends namely Virtual Reality and Augmented Reality. It is a key part of Human-Computer Interaction
Mukthineni Venkat, Mukthineni Rahul, Sharma Onkar, Narayanan Swathi Jamjala   +3 more
doaj   +1 more source

Hand Gesture Recognition Based on Continuous Wave (CW) Radar Using Principal Component Analysis (PCA) and K-Nearest Neighbor (KNN) Methods

JOIV: International Journal on Informatics Visualization, 2022
Human-computer interaction (HCI) is a field of study studying how people and computers interact. One of the most critical branches of HCI is hand gesture recognition, with most research concentrating on a single direction. A slight change in the angle of
Muhammad Khairani Abdul Rahman, Nur Emileen Abdul Rashid, Nor Najwa Ismail, Nor Ayu Zalina Zakaria, Zuhani Ismail Khan, Siti Amalina Enche Ab Rahim, Farah Nadia Mohd Isa   +6 more
doaj   +1 more source

Touchless Operations Using Hand Gestures Detection

, 2023
Humans have only recently begun using hand gestures to interact with computers. The integration of the real and digital worlds is the aim of gesture recognition. It is considerably simpler to convey our intentions and ideas to the computer via hand gestures.
Aryan Gupta, Rachna Narula, Parth Garg, Diksha Joshi, Navneet Upadhyay   +4 more
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source