Results 81 to 90 of about 114,186 (287)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Crossed Aphasia in a Patient with Anaplastic Astrocytoma of the Non-Dominant Hemisphere [PDF]
, 2017 Aphasia describes a spectrum of speech impairments due to damage in the language centers of the brain. Insult to the inferior frontal gyrus of the dominant cerebral hemisphere results in Broca\u27s aphasia - the inability to produce fluent speech.
Anand, Neil +3 more
core +2 more sources
Left- handedness versus right-handedness
, 2020 I am left-handed. I always wonder why people who write with their right hands react so violently seeing me operating with my left hand and often ask such questions as "How do you do this?", "Do you feel comfortable?" So I want to figure out how left-handed children differ from children who write with their right hand.
Ivanova, D. +1 more
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
ARE LEFT HANDED SURGEONS LEFT OUT? [PDF]
, 2012 Being a left-handed surgeon, more specifically a left-handed ENT surgeon, presents a unique pattern of difficulties.This article is an overview of left-handedness and a personal account of the specific difficulties a left-handed ENT surgeon faces.
Kothandaraman, SriKamkshi +1 more
core +1 more source
The Universe of Chaos and Quanta
, 1999 In recent papers it was shown that stochastic processes in the universe as a whole lead to discrete space time at Compton scales as also non-relativistic Quantum Mechanics.
Sidharth, B. G.
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Laterality and cognition: Handedness as a factor differentiating cognitive abilities
Dialogues in Clinical Neuroscience & Mental Health, 2018 Laterality refers to humans’ tendency to prefer one side of their body instead of the other. Τhe inborn lateralization of cerebral hemispheres is most often expressed through the humans’ handedness.
Fotini Bonoti, Filippos Vlachos
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source