Results 51 to 60 of about 1,733,495 (283)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Association between tooth loss and handgrip strength in a general adult population.

PLoS ONE, 2020
Tooth loss is a prevailing condition in China due to the high prevalence of oral diseases. Since previous studies explored the association between tooth loss and handgrip strength showed incongruous results, the aim of this study was to investigate the ...
Ziqi Zhou, Yeqing Gu, Qing Zhang, Li Liu, Hongmei Wu, Ge Meng, Xue Bao, Shunming Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yue Zhao, Kaijun Niu   +14 more
doaj   +1 more source

Relationships Among Metacarpal Bone Mass and Handgrip Strength In 150 Healthy Adult Males [PDF]

, 2004
Bone density and muscle strength are the primary determinants of bone strength. Measurements of grip strength is less costly, less invasive and in combination with metacarpal bone mineral density (BMD) measurements could provide a feasible way of ...
Hicran Uşan, Nesrin Canik Baysal, Canan Esener, Canan Tezel, Afitap İçağasıoğlu   +4 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gender-Specific Association of Handgrip Strength with Type 2 Diabetes Mellitus in Chinese Han Older Adults

Diabetes, Metabolic Syndrome and Obesity, 2023
Qian Huang,1,* Xing Chen,1,2,* Hui Yan Shen,1 Jia Mou Zhou,1 He Qiao Zhang,1 Li Wang,1 Ren Chen,1 Jing Cheng,1 Yan Zhang,1 Dong Mei Zhang,1 Gui Mei Chen1 1School of Health Service Management, Anhui Medical University, Hefei, Anhui Province ...
Huang Q, Chen X, Shen HY, Zhou JM, Zhang HQ, Wang L, Chen R, Cheng J, Zhang Y, Zhang DM, Chen GM   +10 more
doaj  

Handgrip strength in medical students: Correlation with body mass index and hand dimensions

Asian Journal of Medical Sciences, 2018
Background: Handgrip is a predictor of physical fitness, hand functions, and nutritional status. It is affected by many factors including age, sex, body mass index, and hand dimensions.
Jasim N Al-Asadi
doaj   +1 more source

Association Between Handgrip Strength and Fatigability and Cognitive Performance in Adults Aged 65 and Older [PDF]

BACKGROUND/AIMS: To explore the relationship between handgrip strength, fatigability, and cognitive function in older adults. MATERIALS AND METHODS: This cross-sectional study included 89 adults aged 65-85 who were re-ceiving services from a physical ...
Nazemin Gürsoy Karaman, Emine Koç
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source